Russian veterinary journal Russian veterinary journal Российский ветеринарный журнал 2500-4379 53219 10.32416/2500-4379-2022-3-4-37-52 КЛИНИЧЕСКИЙ СЛУЧАЙ CASE REPORT КЛИНИЧЕСКИЙ СЛУЧАЙ Hereditary hyperlipidemia ocular lesions in a decorative domestic rabbit Офтальмологические поражения при наследственной гиперлипидемии у декоративного домашнего кролика Артюшина Юлия Юрьевна Artyushina Yuliya Yur'evna dobro450@mail.ru

кандидат ветеринарных наук;

candidate of veterinary sciences;

 Центр ветеринарной офтальмологии доктора Шилкина А.Г. Москва Россия Ophthalmologyc veterinary center of DVM Shilkin A.G. Moscow Russian Federation 30 09 2022 30 09 2022 2022 37 52 28 09 2022 https://logospress.editorum.ru/en/nauka/article/53219/view

У животных, как и у человека, существенную часть патологий органа зрения составляют функциональные или морфологические изменения, связанные с общими или системными заболеваниями. Выявленные при офтальмологическом исследовании отклонения от нормы в ряде случаев служат симптомами общего патологического процесса и могут способствовать установлению диагноза. В статье рассмотрен клинический случай развития патологических изменений органа зрения у декоративного домашнего кролика (Oryctolagus cuniculus domesticus), сопровождающих наследственное нарушение обмена холестерина в его организме: хронического липогранулематозного конъюнктивита, липоидной дистрофии роговицы, массивной инфильтрации холестерином фиброзной стромы склеры, заднего полюса глазного яблока, гипертрофии жировой клетчатки орбиты. Наблюдаемые патологические процессы в структурах глаз и их придаточного аппарата отличались особой тяжестью проявлений. В статье представлены данные МРТ и фото гистологических препаратов патологически измененных тканей. Клинического описания офтальмологических отклонений при наследственной гиперлипидемии кроликов с тяжестью течения, как в приведенном в статье случае, в доступных научных литературных источниках не представлено.

In animals, as in humans, a significant part of the functional or morphological ophthalmic pathologies are associated with general or systemic diseases. Abnormalities detected during ophthalmological examination, in some cases, are symptoms of a general pathological process and can contribute to the diagnosis. The article discusses the clinical case of the eye pathological changes development in a decorative domestic rabbit (Oryctolagus cuniculus domesticus) accompanying a cholesterol metabolism hereditary disorder: chronic lipogranulomatous conjunctivitis, lipid degeneration of the cornea, massive cholesterol infiltration of the sclera fibrous stroma and eyeball posterior pole, hypertrophy of the orbit fatty cellular tissue. The observed pathological processes in the eyes and their adnexal structures were manifestated severely. The article presents MRI data and photographs of histological preparations of pathologically altered tissues. A clinical description of severe ophthalmic abnormalities in rabbit with hereditary hyperlipidemia as in our article, is not presented in the available scientific literature.

 WHHL-кролик атеросклероз гиперхолестеринемия рецепторы ЛПНП пенистые клетки хронический липогранулематозный конъюнктивит липоидная дистрофия роговицы WHHL-rabbit atherosclerosis hypercholesterolemia LDL receptor deficiency foam cells chronic lipogranulomatous conjunctivitis lipid keratopathy

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