Modern Therapy in Psychiatry and Neurology Journal Modern Therapy in Psychiatry and Neurology Journal Современная терапия в психиатрии и неврологии 2304-9707 122564 10.32416/2304-9707-2026-2-22-27 ПСИХОСОМАТИКА PSYCHOSOMATICS ПСИХОСОМАТИКА Neurobiological foundations of psychosomatic disorders Нейробиологические основы психосоматических расстройств Клюшник Татьяна Павловна Klyushnik Tatyana Pavlovna

доктор медицинских наук;

doctor of medical sciences;

 Омельченко Мария Анатольевна Omel'chenko Mariya Anatol'evna

доктор медицинских наук;

doctor of medical sciences;

 Самушия Марина Антиповна Samushia Marina Antipovna

доктор медицинских наук;

doctor of medical sciences;

 Центральная государственная медицинская академия Управления делами Президента РФ Москва Россия Central State Medical Academy of Department of Presidential Affairs Moscow Russian Federation Центральная государственная медицинская академия Управления делами Президента РФ Москва Россия Central State Medical Academy of Department of Presidential Affairs Moscow Russian Federation Центральная государственная медицинская академия Управления делами Президента РФ Москва Россия Central State Medical Academy of Department of Presidential Affairs Moscow Russian Federation 19 05 2026 19 05 2026 2026 2 22 27 30 04 2026 https://logospress.editorum.ru/en/nauka/article/122564/view

Традиционные методы психиатрической диагностики не могут объяснить сложное взаимодействие между биологическими и психопатологическими факторами, принимающими участие в развитии психосоматической патологии. Это приводит к недостаточному пониманию патогенетических путей ее формирования и, следовательно, неполной терапевтической эффективности. В представленном обзоре анализируются фундаментальные биологические основы развития психосоматических расстройств с участием гипоталамо-гипофизарно-надпочечниковой оси, нейровоспаления, митохондриальной дисфункции, что способствует лучшему пониманию ключевых патогенных факторов и оптимизации стратегий лечения.

Traditional methods of psychiatric diagnosis cannot explain the complex interaction between biological and psychopathological factors involved in the development of psychosomatic pathology. This leads to an insufficient understanding of the pathogenetic pathways of its formation and, consequently, to incomplete therapeutic effectiveness. This review analyzes the fundamental biological basis of the development of psychosomatic disorders involving the hypothalamic-pituitary-adrenal axis, neuroinflammation, and mitochondrial dysfunction, which contributes to a better understanding of key pathogenic factors and the optimization of treatment strategies.

 психосоматические заболевания патогенетические основы коморбидность гипоталамо-гипофизарно-надпочечниковая система нейровоспаление psychosomatic disorders pathogenesis comorbidity hypothalamic-pituitary-adrenal system neuroinflammation

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