Russian veterinary journal Russian veterinary journal Российский ветеринарный журнал 2500-4379 41115 10.32416/2500-4379-2020-2-18-26 ЛЕКЦИИ LECTURES ЛЕКЦИИ Enzootic bovine leucosis Лейкоз крупного рогатого скота Макаров Владимир Владимирович Makarov Vladimir Vladimirovich vvm-39@mail.ru

доктор биологических наук;

doctor of sciences in biology;

 Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов» Москва Россия People's Friendship University of Russian Moscow Russian Federation ФГБУ «Центр ветеринарии» Москва Россия FGBU «Veterinary Center» Moscow Russian Federation 2020 2 18 26 https://logospress.editorum.ru/en/nauka/article/41115/view

В аналитической лекции рассмотрены имеющиеся данные по мало обсуждаемым в отечественной литературе аспектам лейкоза крупного рогатого скота. С современных позиций паразитарной системы интерпретированы важнейшие элементы патобиоза ― передача инфекции, патогенез, его клеточные и вирусологические механизма, провирусная нагрузка и практическое значение ее измерения, заражение потомства и роль инфицированного молодняка в распространении лейкоза.

In an analytical discourse reviewed the available data on aspects of enzootic bovine leucosis that are little discussed in the domestic literature. The most important elements of pathobiosis as a transmission of infection and pathogenesis, its cellular and virological mechanisms, proviral load and the practical significance of its measurement, infection of the of newborns and the role of infected young animals in the spread of leucosis are interpreted from the current position of the parasitic system.

 лейкоз крупный рогатый скот передача инфекции патогенез провирусная нагрузка лейкоз у молодняка enzootic bovine leucosis transmission of infection pathogenesis proviral load leucosis in young animal

Makarov V.V., Grinishin D.P. E`pizootologicheskie perspektivy` lejkoza krupnogo rogatogo skota [Epizootological prospects for the bovine leucosis], Vestnik Rossel`xozakademii [Herald of RAA], 2005, No. 2, pp. 70-73. (In russ.). Makarov V.V., Grinishin D.P. E`pizootologicheskie perspektivy` lejkoza krupnogo rogatogo skota [Epizootological prospects for the bovine leucosis], Vestnik Rossel`xozakademii [Herald of RAA], 2005, No. 2, pp. 70-73. (In russ.). Makarov V.V., Grinishin D.P. PCzR v diagnostike lejkoza krupnogo rogatogo skota [PCR in diagnostics of the bovine leucosis], Veterinariya [Veterinary medicine], 2005, No. 4, pp. 9-11. (In russ.). Makarov V.V., Grinishin D.P. PCzR v diagnostike lejkoza krupnogo rogatogo skota [PCR in diagnostics of the bovine leucosis], Veterinariya [Veterinary medicine], 2005, No. 4, pp. 9-11. (In russ.). Aida Y., Murakami H., Takahashi M., Takeshima S. Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus, Front. Microbiol., 2013, No. 4, pp. 328. doi: 10.3389 / fmicb.2013.00328 Aida Y., Murakami H., Takahashi M., Takeshima S. Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus, Front. Microbiol., 2013, No. 4, pp. 328. doi: 10.3389 / fmicb.2013.00328 EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare), 2015. Scientific opinion on enzootic bovine leukosis, EFSA Journal, 2015, Vol. 13(7), No. 4188, 63 p. doi:10.2903/j.efsa.2015.4188 EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare), 2015. Scientific opinion on enzootic bovine leukosis, EFSA Journal, 2015, Vol. 13(7), No. 4188, 63 p. doi:10.2903/j.efsa.2015.4188 Hanon E., Stinchcombe J., Saito M., Asquith B., Taylor G., Tanaka Y., Weber J., Griffiths G., Bangham C. Fratricide among CD81 T Lymphocytes Naturally Infected with Human T Cell Lymphotropic Virus Type I, Immunity, 2000, Vol. 13, pp. 657-664. Hanon E., Stinchcombe J., Saito M., Asquith B., Taylor G., Tanaka Y., Weber J., Griffiths G., Bangham C. Fratricide among CD81 T Lymphocytes Naturally Infected with Human T Cell Lymphotropic Virus Type I, Immunity, 2000, Vol. 13, pp. 657-664. Höllsberg P., Mechanisms of T-cell activation by human T-cell lymphotropic virus type I, Microbiology and Molecular Biology Reviews, 1999, No. 63, pp. 308-333. Höllsberg P., Mechanisms of T-cell activation by human T-cell lymphotropic virus type I, Microbiology and Molecular Biology Reviews, 1999, No. 63, pp. 308-333. Hoshino H. Cellular factors involved in HTLV-1 entry and pathogenicit. Front. Microbio., 2012, No. 3, pp. 222. doi: 10.3389/fmicb.2012.0022. Hoshino H. Cellular factors involved in HTLV-1 entry and pathogenicit. Front. Microbio., 2012, No. 3, pp. 222. doi: 10.3389/fmicb.2012.0022. Gutiérrez G., Merlini R., Alvarez R., Rondelli F., Dynamics of perinatal bovine leukemia virus infection, BMC Veterinary Research, 2014, No. 10(1), pp. 82. doi: 10.1186 / 1746-6148-9-95. Gutiérrez G., Merlini R., Alvarez R., Rondelli F., Dynamics of perinatal bovine leukemia virus infection, BMC Veterinary Research, 2014, No. 10(1), pp. 82. doi: 10.1186 / 1746-6148-9-95. Igakura T., Stinchcombe J., Goon P., Taylor G., Weber J., Griffiths G., Tanaka Y., Osame M., Bangham C., Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton, Science, 2003, No. 299, pp. 1713-1716. Igakura T., Stinchcombe J., Goon P., Taylor G., Weber J., Griffiths G., Tanaka Y., Osame M., Bangham C., Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton, Science, 2003, No. 299, pp. 1713-1716. Juliarena M., Barrios C., Lützelschwab C., Esteban E., Bovine leukemia virus: current perspectives, Virus Adaptation and Treatment, 2017, Vol. 9, pp. 13-26. doi.org/10.2147/VAAT.S113947 Juliarena M., Barrios C., Lützelschwab C., Esteban E., Bovine leukemia virus: current perspectives, Virus Adaptation and Treatment, 2017, Vol. 9, pp. 13-26. doi.org/10.2147/VAAT.S113947 Juliarena M., Gutierrez S., Ceriani C., Determination of proviral load in bovine leukemia virus-infected cattle with and without lymphocytosis, Am. J. Vet. Res., 2007 Nov, No. 68 (11), pp. 1220-5. DOI: 10.2460 / ajvr.68.11.1220 Juliarena M., Gutierrez S., Ceriani C., Determination of proviral load in bovine leukemia virus-infected cattle with and without lymphocytosis, Am. J. Vet. Res., 2007 Nov, No. 68 (11), pp. 1220-5. DOI: 10.2460 / ajvr.68.11.1220 Kajiyama W., Kashiwagi J., Ikematsu H., Hayashi H., Nomura H., Okōchi K., Intrafamilial clustering of anti-ATLA-Positive persons, Am J Epldemiol, 1988, No. 124, pp. 800-806. Kajiyama W., Kashiwagi J., Ikematsu H., Hayashi H., Nomura H., Okōchi K., Intrafamilial clustering of anti-ATLA-Positive persons, Am J Epldemiol, 1988, No. 124, pp. 800-806. Maguer-Satta V., Duc Dodon M., Human immature thymocytes as target cells of the leukemogenic activity of human T-cell leukemia virus type I, Blood, 1995, No. 86(4), pp. 1444-1452. DOI: 10.1182/blood. Maguer-Satta V., Duc Dodon M., Human immature thymocytes as target cells of the leukemogenic activity of human T-cell leukemia virus type I, Blood, 1995, No. 86(4), pp. 1444-1452. DOI: 10.1182/blood. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, 2019 https://www.oie.int/en/standard-setting/terrestrial-manual/access-online/ Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, 2019 https://www.oie.int/en/standard-setting/terrestrial-manual/access-online/ Mazzarello A., Fitch M., Hellerstein M., Chiorazzi N., Measurement of Leukemic B-Cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia, Methods Mol. Biol., 2019, No. 1881, pp. 129-151. doi: 10.1007 / 978-1-4939-8876-1_11. Mazzarello A., Fitch M., Hellerstein M., Chiorazzi N., Measurement of Leukemic B-Cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia, Methods Mol. Biol., 2019, No. 1881, pp. 129-151. doi: 10.1007 / 978-1-4939-8876-1_11. Mekata H., Sekiguchi S., Konnai S., Kirino Y., Honkawa K., Nonaka N., Horii Y., Norimine J., Evaluation of the natural perinatal transmission of bovine leukaemia virus, Vet. Record., 2015, No. 176(10), pp. 274. http://dx.doi.org/10.1136/vr.102464 Mekata H., Sekiguchi S., Konnai S., Kirino Y., Honkawa K., Nonaka N., Horii Y., Norimine J., Evaluation of the natural perinatal transmission of bovine leukaemia virus, Vet. Record., 2015, No. 176(10), pp. 274. http://dx.doi.org/10.1136/vr.102464 Mekata H., Yamamoto M., Hayashi T., Kirino Y., Sekiguchi S., Konnai S., Horii Y., Norimine J., Cattle with a low bovine leukemia virus proviral load are rarely an infectious source, Japanese J. of Vet. Res., 2018, No. 66(3), pp. 157-163. doi: 10.14943/jjvr.66.3.157 Mekata H., Yamamoto M., Hayashi T., Kirino Y., Sekiguchi S., Konnai S., Horii Y., Norimine J., Cattle with a low bovine leukemia virus proviral load are rarely an infectious source, Japanese J. of Vet. Res., 2018, No. 66(3), pp. 157-163. doi: 10.14943/jjvr.66.3.157 Messmer B., Messmer D., Allen S., Kudalkar P., Cesar D., Murphy E., Koduru P., Ferrarini M., Zupo S., Cutrona G., Damle R., Wasil T., Rai K., Hellerstein M., Chorazzi N., In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells, J. Clin. Invest. , 2005 Mar, No. 115(3), pp. 755-764. Messmer B., Messmer D., Allen S., Kudalkar P., Cesar D., Murphy E., Koduru P., Ferrarini M., Zupo S., Cutrona G., Damle R., Wasil T., Rai K., Hellerstein M., Chorazzi N., In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells, J. Clin. Invest. , 2005 Mar, No. 115(3), pp. 755-764. Mirsky M., Olmstead C., Da Y., Lewin H., The prevalence of proviral bovine leukemia virus in peripheral blood mononuclear cells at two subclinical stages of infection, J. Virol., 1996, No. 70 (4), pp. 2178-2183. Mirsky M., Olmstead C., Da Y., Lewin H., The prevalence of proviral bovine leukemia virus in peripheral blood mononuclear cells at two subclinical stages of infection, J. Virol., 1996, No. 70 (4), pp. 2178-2183. Panei C.J., Takeshima S.N., Omori T., Nunoya T., Davis W., Ishizaki H., Matoba K., Aida Y., Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV-CoCoMo-qPCR, BMC Vet. Res. 2013;, No. 9, pp. 95. DOI: 10.1186/1746-6148-9-95. Panei C.J., Takeshima S.N., Omori T., Nunoya T., Davis W., Ishizaki H., Matoba K., Aida Y., Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV-CoCoMo-qPCR, BMC Vet. Res. 2013;, No. 9, pp. 95. DOI: 10.1186/1746-6148-9-95. Ruiz V., Porta N., Lomónaco M., Trono K., Alvarez I., Bovine Leukemia Virus Infection in Neonatal Calves. Risk Factors and Control Measures. Front. Vet. Sci., 2018, No. 5, pp. 267. doi: 10.3389/fvets.2018.00267. Ruiz V., Porta N., Lomónaco M., Trono K., Alvarez I., Bovine Leukemia Virus Infection in Neonatal Calves. Risk Factors and Control Measures. Front. Vet. Sci., 2018, No. 5, pp. 267. doi: 10.3389/fvets.2018.00267. Samitas K., Lötvall J., Bossios A. B cells: from early development to regulating allergic diseases, Arch Immunol Ther Exp (Warsz), 2010, Vol. 58, Is. 3, pp. 209-225. doi:10.1007/s00005-010-0073-2. Samitas K., Lötvall J., Bossios A. B cells: from early development to regulating allergic diseases, Arch Immunol Ther Exp (Warsz), 2010, Vol. 58, Is. 3, pp. 209-225. doi:10.1007/s00005-010-0073-2. Schwartz I., Bensaid A., Polack B., Perrin B., Berthelemy M., Levy D., In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle, Journal of Virology, 1994, No. 68 (7), pp. 4589-96, doi: 10.1128/JVI.68.7.4589-4596.1994. Schwartz I., Bensaid A., Polack B., Perrin B., Berthelemy M., Levy D., In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle, Journal of Virology, 1994, No. 68 (7), pp. 4589-96, doi: 10.1128/JVI.68.7.4589-4596.1994. Sherer N., Lehmann M., Jimenez-Soto L., Horensavitz C., Pypaert M., Mothes W., Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission, Nat Cell Biol., 2007, No. 9, pp. 310-315. [PubMed: 17293854]. Sherer N., Lehmann M., Jimenez-Soto L., Horensavitz C., Pypaert M., Mothes W., Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission, Nat Cell Biol., 2007, No. 9, pp. 310-315. [PubMed: 17293854]. Watanuki S., Takeshima S., Borjigin L., Sato H., Bai L., Murakami H., Aida Y., Visualizing bovine leukemia virus (BLV)-infected cells and measuring BLV proviral loads in the milk of BLV seropositive dams. Vet Res., 2019 Nov, Vol. 29, No. 50(1), pp. 102. doi: 10.1186/s13567-019-0724-1. Watanuki S., Takeshima S., Borjigin L., Sato H., Bai L., Murakami H., Aida Y., Visualizing bovine leukemia virus (BLV)-infected cells and measuring BLV proviral loads in the milk of BLV seropositive dams. Vet Res., 2019 Nov, Vol. 29, No. 50(1), pp. 102. doi: 10.1186/s13567-019-0724-1.