The article describes the history of the creation of vaccines against the foot-and-mouth disease since the first attempts to control the disease to modern time, as well as the successes achieved in the prevention and eradication of foot-and-mouth disease in the 20th century in various countries of the world using various control programs, including vaccination. The stages of research and practical application of vaccines against the foot-and-mouth disease are consistently indicated, how and by whom the technologies for the manufacture of vaccines against this disease were developed, the experience of their application has led to the fact that now many countries of the world are free from the foot-and-mouth disease. This information remains useful for the Russian reader in connection with the registration of the foot-and-mouth disease in our countr