Russian veterinary journal Russian veterinary journal Российский ветеринарный журнал 2500-4379 41118 10.32416/2500-4379-2020-2-39-42 СОВРЕМЕННЫЕ ФАРМАКО- И БИОПРЕПАРАТЫ MODERN PHARMACOLOGICAL DRUGS & BIOPREPARATIONS СОВРЕМЕННЫЕ ФАРМАКО- И БИОПРЕПАРАТЫ On efficacy of Catobevit in subclinical ketosis of lactating cows Некоторые аспекты применения препарата Катобевит при субклиническом кетозе у коров Татарчук Олег Петрович Tatarchuk Oleg Petrovich oleg.tatarchuk@krka.biz ООО «КРКА ФАРМА» Москва Россия KRKA FARMA LLC Moscow Russian Federation 2020 2 39 42 https://logospress.editorum.ru/en/nauka/article/41118/view

Соотношение действующих веществ в фиксированной комбинации «цианокобаламин и бутафосфан» должно быть стабильным на протяжении срока годности препарата, иначе эффективность лечения субклинического кетоза у лактирующих коров может быть недостаточной. В исследовании обнаружено, что эффективность препарата Катобевит при субклиническом кетозе у молочных коров была выше, чем у препарата сравнения с иным составом вспомогательных веществ.

Ratio of active ingredients in combined cyanocobalamin and butafosfan injectable solution has to remain constant in storage; otherwise, the distorted ratio would lead to diminished efficacy in the treatment of subclinical ketosis in dairy cattle. It has been found that efficacy of Catobevit (fixed combination of cyanocobalamine and butafosfan) in the treatment of subclinical ketosis in lactating cows is superior as compared to reference combination having slightly different vehicles composition.

 кетоз кетонемия гипогликемия цианокобаламин бутафосфан ketosis ketonemia hypoglycemia cyanocobalamin butafosfan

Koshhaev A.G., Usenko V.V., Lixoman A.V., Komarova N.S., Glikemiya kak osnovnoj marker metabolicheskix narushenij u korov v perexodny`j period [Glycemia as the basic marker of metabolic disturbances in cows in the transition period], Zootexniya [Zootechny], 2016, No 1, pp. 19-20. (In russ.) Koshhaev A.G., Usenko V.V., Lixoman A.V., Komarova N.S., Glikemiya kak osnovnoj marker metabolicheskix narushenij u korov v perexodny`j period [Glycemia as the basic marker of metabolic disturbances in cows in the transition period], Zootexniya [Zootechny], 2016, No 1, pp. 19-20. (In russ.) Urazaev N.A., Profilaktika narusheniya obmena veshhestv u KRS [Preventive maintenance of the disturbance of exchange of substances in cows], Leningrad, Agropromizdat, 1986, 159 p. (In russ.) Urazaev N.A., Profilaktika narusheniya obmena veshhestv u KRS [Preventive maintenance of the disturbance of exchange of substances in cows], Leningrad, Agropromizdat, 1986, 159 p. (In russ.) Baird G.D., Primary ketosis in the high-producing dairy cow: clinical and subclinical disorders, treatment, prevention, and outlook., J. Dairy Sci., 1982, No. 65, pp. 1-10. Baird G.D., Primary ketosis in the high-producing dairy cow: clinical and subclinical disorders, treatment, prevention, and outlook., J. Dairy Sci., 1982, No. 65, pp. 1-10. Bruss M.L., Lipids and Ketones. Clinical Biochemistry of Domestic Animals, 2008, pp. 81-115. Bruss M.L., Lipids and Ketones. Clinical Biochemistry of Domestic Animals, 2008, pp. 81-115. Melendez P., Ketosis: Dairy Cattle, Blackwell's Five-Minute Veterinary Consult: Ruminant, 2nd Edition, 2017, pp. 426-427. Melendez P., Ketosis: Dairy Cattle, Blackwell's Five-Minute Veterinary Consult: Ruminant, 2nd Edition, 2017, pp. 426-427. Nuber U., Van Dorland H.A., Bruckmaier R. Effects of butafosfan with or without cyanocobalamin on the metabolism of early lactating cows with subclinical ketosis. Journal of Animal Physiology and Animal Nutrition. 2015, Vol. 100, No. 1, pp. 146-155. Nuber U., Van Dorland H.A., Bruckmaier R. Effects of butafosfan with or without cyanocobalamin on the metabolism of early lactating cows with subclinical ketosis. Journal of Animal Physiology and Animal Nutrition. 2015, Vol. 100, No. 1, pp. 146-155.