Russian veterinary journal Russian veterinary journal Российский ветеринарный журнал 2500-4379 98607 10.32416/2500-4379-2025-2-45-54 СОВРЕМЕННЫЕ ФАРМАКО- И БИОПРЕПАРАТЫ MODERN PHARMACOLOGICAL DRUGS & BIOPREPARATIONS СОВРЕМЕННЫЕ ФАРМАКО- И БИОПРЕПАРАТЫ Therapeutic potential and safety of the combination of gabapentin and succinate trazodone (Trazapentine® tablets) for the control of feline idiopathic cystitis: from acute episodes to long-term prevention Терапевтический потенциал и безопасность комбинации габапентина и сукцината тразодона (Тразапентин® таблетки) для контроля идиопатического цистита кошек: от острых эпизодов к долгосрочной профилактике Белоглазов Денис Валерьевич Beloglazov Denis Valer'evich

кандидат биологических наук;

candidate of sciences in biology;

 Елизарова Елена Анатольевна Elizarova Elena Anatol'evna anatomifarmitox@mail.ru

кандидат биологических наук;

candidate of sciences in biology;

 Мукасеев Сергей Владимирович Mukaseev Sergey Vladimirovich

кандидат ветеринарных наук;

candidate of veterinary sciences;

 Пархоменко Сергей Александрович Parhomenko Sergey Aleksandrovich Зейналов Орхан Ахмедович Zeynalov Orhan Ahmedovich

кандидат биологических наук;

candidate of sciences in biology;

 ООО «НПК «СКиФФ» Москва Россия LLC «NPC «SKiFF» Moscow Russian Federation ООО «АГ «Аспект» Москва Россия LLC AG Aspect Moscow Russian Federation ООО «НВП «Астрафарм» Москва Россия LLC «RDE «Astrapharm» Moscow Russian Federation Федеральное государственное бюджетное учреждение высшего образования «Нижегородская сельскохозяйственная академия» Нижний Новгород Россия Nizhny Novgorod State Agricultural Academy Nizhnij Novgorod Russian Federation «Центр ветеринарной помощи» Дзержинск Россия «Center of the veterinary aid» Dzerzhinsk Russian Federation ФГБОУ ВО «Нижегородский государственный агротехнологический университет имени Л.Я. Флорентьева» (НГАТУ) Нижний Новгород Россия FSBEIo HE «Nizhny Novgorod State Agrotechnological University named after L.Ya. Florentiev» (NNSAU) Nizhny Novgorod Russian Federation ООО «НПК «СКиФФ» Москва Россия LLC «NPC «SKiFF» Moscow Russian Federation ООО «АГ «Аспект» Москва Россия LLC «AG «Aspect» Moscow Russian Federation ООО «НВП «Астрафарм» Москва Россия LLC «RDE «Astrapharm» Moscow Russian Federation ООО «БиоФерон» Москва Россия LLC «BioFeron» Moscow Russian Federation ООО «НВП «Астрафарм» Москва Россия LLC «RDE «Astrapharm» Moscow Russian Federation ООО «НПК «СКиФФ» Москва Россия LLC «NPC «SKiFF» Moscow Russian Federation ООО «НВП «Астрафарм» Москва Россия LLC «RDE «Astrapharm» Moscow Russian Federation ООО «БиоФерон» Москва Россия LLC «BioFeron» Moscow Russian Federation 19 05 2025 19 05 2025 2025 2 45 54 09 05 2025 https://logospress.editorum.ru/en/nauka/article/98607/view

Результаты проведенного исследования демонстрируют высокую эффективность и безопасность единственного на рынке комбинированного препарата Тразапентин® (габапентин и сукцинат тразодона) для контроля идиопатического цистита кошек и профилактики его рецидивов. Анализ клинических данных показал, что его применение в течение 7 дней привело к значительному снижению выраженности симптомов. Улучшение общего состояния кошек сопровождалось снижением уровня боли, прекращением вокализации, отсутствием гематурии, нормализацией частоты и качества посещения лотка, удовлетворительным опорожнением мочевого пузыря, восстановлением аппетита и социальной активности, что свидетельствует о мультимодальном воздействии препарата на психонейроэндокринный статус животных, страдающих идиопатическим циститом. Применение препарата Тразапентин® в течение 180 дней обеспечивало устойчивый положительный профилактический эффект. Число случаев идиопатического цистита в опытной группе снизилось в 7 раз по сравнению с группой плацебо, что подтверждает его способность предотвращать рецидивы заболевания. Более того, у кошек, получавших препарат, отмечалось сокращение средней продолжительности эпизода рецидива на 41%, что является значительным показателем улучшения качества жизни животных.

The results of the conducted study demonstrate the high efficacy and safety of the unique combined drug Trazapentin® (gabapentin and succinate trazodone) on the market for the control of feline idiopathic cystitis and prevention of its relapses. Analysis of clinical data showed that its use for 7 days led to a significant reduction in symptom severity. Improvement in the general condition of cats was accompanied by a decrease in pain lev-els, cessation of vocalization, absence of hematuria, normalization of the frequency and quality of litter box visits, satisfactory bladder emptying, restoration of appetite and social activity. This indicates the multimodal effect of the drug on the psychoneuroendocrine status of animals suf-fering from idiopathic cystitis. The use of Trazapentin® for 180 days provided a stable positive preventive effect. The number of feline idiopathic cystitis cases in the experimental group decreased by 7 times com-pared to group of placebo, confirming its ability to prevent idiopathic cystitis relapses. Moreover, cats re-ceiving the drug showed a 41% reduction in the average duration of relapse episodes, which is a significant indicator of improved animal quality of life.

 Тразапентин® габапентин сукцинат тразодона тразодон идиопатический цистит кошек Trazapentin® gabapentin succinate trazodone trazodone feline idiopathic cystitis

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