ON THE ISSUE OF TREATMENT OF FOCAL EPILEPSY IN FAMILY MEDICINE
Abstract and keywords
Abstract:
Epilepsy is a chronic neurological disorder of various etiologies. This pathology is accompanied by seizures, convulsive or non-convulsive, with or without loss of consciousness. The disease has an organic nature, but epilepsy is heterogeneous, that is, it can have different symptoms, causes, and types of seizures. Epilepsy is one of the most common neurological pathologies. At least 65 million people in the world have this diagnosis, and people of all ages and genders are ill. However, epileptic seizures occur more often in old age, increasing the incidence of strokes, neurodegenerative diseases and tumors in this group. The article examines the issues of instrumental diagnosis and pharmacological treatment of focal epilepsy, compares the mechanism of action and safety of antiepileptic drugs (AEDs).

Keywords:
focal epilepsy, antiepileptic drugs, resistance, diagnosis, electroencephalogram, magnetic resonance imaging
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References

1. Bai Y.F, Zeng C, Jia M, Xiao B. Molecular mechanisms of topiramate and its clinical value in epilepsy. *Seizure*. 2022 May;98:51-56.

2. Battino D, Tomson T, Bonizzoni E, Craig J, Perucca E, Sabers A, Thomas S, Alvestad S, Perucca P, Vajda F; EURAP Collaborators. Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy. JAMA Neurol. 2024 May 1;81(5):481-489.

3. Basit H, Kahwaji CI. Clonazepam. 2023 May 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.

4. Beghi E. The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185-191.

5. Benbadis SR, Beniczky S, Bertram E, MacIver S, Moshé SL. The role of EEG in patients with suspected epilepsy. Epileptic Disord. 2020 Apr 1;22(2):143-155.

6. Costa B, Vale N. Understanding Lamotrigine's Role in the CNS and Possible Future Evolution. Int J Mol Sci. 2023 Mar 23;24(7):6050.

7. Gidal BE, Resnick T, Smith MC, Wheless JW. Zonisamide: A Comprehensive, Updated Review for the Clinician. Neurol Clin Pract. 2024 Feb;14(1): e200210.

8. Hakami T. Neuropharmacology of Antiseizure Drugs. Neuropsychopharmacol Rep. 2021 Sep;41(3):336-351.

9. Lapalme-Remis S, Nguyen DK. Neuroimaging of Epilepsy. Continuum (Minneap Minn). 2022 Apr 1; 28(2):306-338.

10. Löscher W, Gillard M, Sands ZA, Kaminski RM, Klitgaard H. Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond. CNS Drugs. 2016 Nov;30(11):1055-1077.

11. Löscher W, Potschka H, Sisodiya SM, Vezzani A. Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options. Pharmacol Rev. 2020 Jul;72(3):606-638.

12. Lőrincz-Molnár T, Siegler Z, Hegyi M, Jakus R, Bodó T, Kormos E, Fogarasi A. A tartós videó-EEG-monitorozás szerepe a gyermekkori epilepsziák diagnosztikájában [The role of long-term video-EEG monitoring in the diagnosis of childhood epilepsies]. Orv Hetil. 2024 May 12;165(19):722-726. Hungarian.

13. Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators. The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet. 2021 Apr 10;397(10282):1363-1374.

14. Mitra-Ghosh T, Callisto SP, Lamba JK, Remmel RP, Birnbaum AK, Barbarino JM, Klein TE, Altman RB. PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2020 Jun; 30(4):81-90.

15. Reyes Fernandez PC, Wright CS, Warden SJ, Hum J, Farach-Carson MC, Thompson WR. Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues. Curr Osteoporos Rep. 2022 Dec;20(6):365-378.

16. Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M. Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun. 2024 Apr 18;15(1):3027.

17. Yan, Raowei et al. Sodium channel blockers for the treatment of focal epilepsy: A Chinese expert consensus. Seizure - European Journal of Epilepsy, Volume 127, 105 – 114.

18. Zhao W, Li Y, Sun H, Zhang W, Li J, Jiang T, Jiang L, Meng H. Effect of intranasal and oral administration of levetiracetam on the temporal and spatial distributions of SV2A in the KA-induced rat model of SE. J Cell Mol Med*. 2023 Dec;27(24):4045-4055.

19. Burd S.G., Lebedeva A.V., Mironov M.B., Avakyan G.G., Rubleva Yu.V. Prioritety v naznachenii protivoepilepticheskih preparatov pacientam s epilepsiey po rezul'tatam oprosa vrachey-nevrologov. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2018;118(5):36‑38.

20. Naumova G.I., Vlasov P.N., Prusakova O.I., Usol'ceva A.A., Shnayder N.A., Dmitrenko D.V. Otmena preparatov val'proevoy kisloty vo vremya beremennosti pri epilepsii. Nevrologiya, neyropsihiatriya, psihosomatika. 2023;15(2):27-33.

21. Tursunov, A. N. Molekulyarnye mehanizmy deystviya val'proevoy kisloty na signal'nye sistemy i funkcionirovanie mozga / A. N. Tursunov, D. S. Vasil'ev, N. N. Nalivaeva // Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova. – 2023. – T. 109, № 10. – S. 1331-1348.

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