employee
«VETUCHASTOK» LLC (General Director)
CSCSTI 68.41
Objective. To evaluate the efficacy and safety of subcutaneous administration of Vetcoxib® (containing 20 mg/ml of robenacoxib) as part of an opioid‑free premedication regimen for neurosurgical procedures in dogs and cats. Materials and methods. A prospective controlled study (n = 30) was conducted: experimental groups (n = 20): dogs (n = 10) and cats (n = 10) receiving premedication with Vetcoxib® + adjuvants; control group (n = 10): standard premedication (maropitant + antibiotic) without NSAIDs or opioids. The following parameters were assessed: intraoperative parameters (sevoflurane dose, hypotension); early postoperative period (pain, time to first food intake, vomiting); long‑term outcomes (relapses, neurological status, quality of life). Statistical analysis was performed using the Mann‑Whitney U‑test, with a significance level of p < 0.05. Results. In the experimental groups: a 25…30 % reduction in sevoflurane dose (p < 0.001; no cases of hypotension (0 %, compared to 30 % hypotension in the control group, p < 0.01); a five‑fold reduction in the need for additional analgesics (0…10 % vs 50 % in the control group, p < 0.001); a 55…63 % decrease in pain intensity (p < 0.0001); a 65…70 % reduction in time to first food intake (p < 0.001). At the 6‑month follow‑up: an improvement in quality of life of 23…27 % (compared to 12…16 % in the control group p < 0.001). Conclusion. The opioid‑free protocol with Vetcoxib® demonstrates high efficacy and safety, and is recommended for implementation in veterinary practice for neurosurgical interventions in ASA I–II patients out contraindications to NSAIDs.
Vetcoxib®, robenacoxib, small domestic animals, neurosurgery, multimodal analgesia, opioid-free analgesia, pharmacokinetics, CMPS-SF, Glasgow CMPS.
1. American Society of Anesthesiologists (ASA) Physical Status Classification System, 2020. ‒ https://sedatium.com/wp-content/uploads/2021/03/ASA-Physical-Status-Classification-System-Diciembre-2020-American-Society-of-Anesthesiologists.pdf
2. Bennett, R.C. Canine Brief Pain Inventory (CBPI): validation of a client‑based assessment tool in a clinical setting / R.C. Bennett et al. // Journal of Small Animal Practice. ‒ 2015. ‒ Vol. 56. ‒ No. 1. ‒ pp. 3-11.
3. Gaynor, J.S. Development of the Colorado State University Canine Acute Pain Scale (CMPS‑SF) / J.S. Gaynor et al. // Journal of the American Animal Hospital Association. ‒ 2007. ‒ Vol. 43. ‒ No. 5. ‒ pp. 271-282.
4. Gerasimchik, V.A. Therapeutic efficacy of Vetcoxib in dogs and cats / V.A. Gerasimchik, E.V. Makeenko, E.S. Eremeev // Veterinary Medicine. ‒ 2023. ‒ Vol. 12. ‒ No. 3. ‒ pp. 28-31.
5. Kongara, K. Pharmacokinetics and pharmacodynamics of robenacoxib in cats and dogs: a review / K. Kongara, J.P. Chambers // Journal of Veterinary Pharmacology and Therapeutics. ‒ 2022. ‒ Vol. 45. ‒ No. 2. ‒ pp. 112-125.
6. Lascelles, B.D.X. Multimodal analgesia in veterinary practice / B.D.X. Lascelles, S.A. Robertson // Veterinary Clinics of North America: Small Animal Practice. ‒ 2021. ‒ Vol. 51. ‒ No. 4. ‒ pp. 705-723.
7. Reid, J. Glasgow composite measure pain scale (CMPS): development and validation / J. Reid et al. // Veterinary Anaesthesia and Analgesia. ‒ 2007. ‒ Vol. 34. ‒ No. 6. ‒ pp. 477-484.
8. WSAVA Pain Management Guidelines, 2023. ‒ https://wsava.org/global-guidelines/pain-guidelines/
9. Instrukciya po primeneniyu preparata Vetkoksib® (Vetcoxibum), OOO «VETUChASTOK», 2025. ‒ https://vetcoxib.ru/
10. Robertson, S.A. The use of non-steroidal anti drugs in veterinary medicine: current perspectives / S.A. Robertson et al. // Veterinary Record. ‒ 2024. ‒ Vol. 194. ‒ No. 8. ‒ e1234-e1245.
11. Steagall, P.V.M. Analgesic protocols in small animal surgery: a systematic review / P.V.M. Steagall et al. // Veterinary Anaesthesia and Analgesia. ‒ 2023. ‒ Vol. 50. ‒ No. 3. ‒ pp. 256-268.
12. Taylor, P.M. Pain assessment in animals: recent advances and ongoing challenges / P.M. Taylor, P.V.M. Steagall // Journal of Comparative Pathology. ‒ 2022. ‒ Vol. 189. ‒ pp. 1-12.
