Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
GRNTI 68.41 Ветеринария
The innate immune system in mammals is closely related to the hemostatic system. In recent years, there has been an accumulation of knowledge proving that these two systems not only interact closely, but are also linked by common molecular and cellular regulatory mechanisms. The study of these mechanisms is important to develop new approaches to the correction of hemostatic disorders, infectious diseases and other pathological conditions in productive animals. Analyzed in this review are results of the use of some modern medications for the correction of hemostatic disorders and increasing nonspecific resistance in calves. The main attention is devoted to gamavit (GM) and phosprenyl (PP), which are widely used in veterinary medicine and animal husbandry. Many studies have shown a positive effect of GM and PP on the innate immune system indices in newborn calves, both in normal state and in various pathological conditions, including infectious diseases, anemia, etc. There was an increase in the phagocytic activity of neutrophils and phagocytic number, an increase in bactericidal and lysozyme activity of blood serum, a decrease in the incidence of non-specific bronchopneumonia in calves, and an increase in live weight gain during the milk growing period. Under the influence of GM and AF, in calves with iron-deficient anemia and/or dyspepsia increase of antioxidant protection was observed as well as normalization of hemostasis, reducing the risk of thrombotic complications to a minimum. The correction of anemia and normalization of the blood formula were also noted. The most effective in correcting hemostasis was GM, which was shown to normalize many impaired platelet functions. Given the fact that platelets serve as an important link in innate immunity, it can be assumed that, at least partially, the immune-stimulating effect of GM may be mediated through these cells.
calves, hemostasis, anemia, coagulation, innate immunity, platelets, gamavit, phosprenyl, blood, sodium nucleinate, toll-like receptors, pattern recognition receptors
1. Abramova, I.A. Povyshenie immunologicheskoy zaschity organizma novorozhdennyh telyat / I.A. Abramova, E.K. Akmatova, K.A. Soburov // Izvestiya VUZov. - 2011. - № 5. - S. 124-126.
2. Alehin, Yu.R. Vliyanie sovremennyh tehnologiy na razvitie i zdorov'e telyat / Yu.R. Alehin, S.R. Uzhahov // Molochnaya promyshlennost'. - 2015. - № 10. - S. 67-68.
3. Annikov, V.V. Produkciya somatotropnogo gormona u podsosnyh porosyat pod vliyaniem gamavita / V.V. Annikov, D.I. Timohin, A.V. Sanin, A.N. Narovlyanskiy, A.V. Pronin // Materialy Mezhdunarodnoy nauchno-prakticheskoy konferencii «Aktual'nye problemy veterinarnoy mediciny, pischevyh i biotehnologiy». - Saratov, 27-28 fevralya, 2018 g. - S. 26-29.
4. Belova, T.A. Vozdeystvie ekstrakta hvoi na aktivnost' gemostaza u novorozhdennyh telyat s funkcional'nymi narusheniyami pischevareniya / T.A. Belova // Veterinariya, zootehniya i biotehnologiya. - 2015. - № 4. - S. 40-45.
5. Gashkov, N.A. Vliyanie preparatov prirodnogo proishozhdeniya na morfologicheskiy i biohimicheskiy sostav krovi telyat rannego vozrasta / N.A. Gashkov // Materialy Vserossiyskoy nauchno-prakticheskoy konferencii «Nauchnoe obespechenie bezopasnosti i kachestva produkcii zhivotnovodstva». - Kurgan, 17 maya 2018 g. - S. 27-30.
6. Grigor'eva, E.A. Vozdeystvie preparata Gamavit na aktivnost' estestvennyh killernyh kletok / E.A. Grigor'eva, A.V. Pronin, A.V. Sanin, A.N. Narovlyanskiy, T.N. Kozhevnikova, T.Yu. Timofeeva, V.Yu. Sanina, T.N. Stepanova, E.V. Gerasimova, A.M. Ivanova // Veterinariya Kubani. - 2016. - № 4. - S. 27-28.
7. Gulyukin, M.I. Veterinarnaya nauka na strazhe prodovol'stvennoy bezopasnosti Rossii / M.I. Gulyukin, A.V. Sanin, A.V. Deeva, A.N. Narovlyanskiy, A.V. Pronin, T.N. Kozhevnikova, M.N. Ravilov, V.D, Kabanov, R.V. Belousova // Agrarnaya nauka. - 2016. - № 4. - S.21-23.
8. Disyuk, E.A. Vliyanie immunostimulyatorov na organizm telyat. / E.A. Disyuk // Materialy Vserossiyskoy nauchno-prakticheskoy konferencii «Nauchnoe obespechenie bezopasnosti i kachestva produkcii zhivotnovodstva». - Kurgan, 17 maya 2018 g. - S. 34-37.
9. Zavalishina, S.Yu. Sosudistyy gemostaz u novorozhdennyh telyat pri zhelezodeficitnoy anemii / S.Yu. Zavalishina // Veterinariya. - 2012. - № 5. - S. 43-45.
10. Zavalishina, S.Yu. Funkcional'nye svoystva koagulyacionnogo gemostaza u novorozhdennyh telyat s deficitom zheleza, poluchavshih ferroglyukin, fosprenil i gamavit / S.Yu. Zavalishina, I.N. Medvedev // Zootehniya. - 2016. - № 11. - S. 24-27.
11. Zayceva, L.G. Korrekciya funkcional'noy aktivnosti peritoneal'nyh makrofagov myshey fosprenilom i gamavitom pri vvedenii vysokih doz al'fa-toksina Staphylococcus aureus / L.G. Zayceva, V.A. Behalo, I.K. Vasil'ev, R.S. Godunov, I.V. Kireeva, T.N. Kozhevnikova, E.V. Nagurskaya, A.N. Narovlyanskiy, S.V. Ozherelkov, A.V. Pronin, A.V. Sanin // Zhurnal mikrobiologii, epidemiologii i immunobiologii. - 2005. - № 6. - S. 51-57.
12. Inyakina, K.A. Puti povysheniya vosproizvoditel'noy sposobnosti korov i sohrannosti novorozhdennyh telyat / K.A. Inyakina, G.M. Topuriya // Izvestiya Orenburgskogo gosudarstvennogo agrarnogo universiteta. - 2008. - № 4 (20). - S. 56-57.
13. Krapivina, E.V. Fiziologicheskaya dinamika gematologicheskih i gemostaticheskih pokazateley u oslablennyh telyat i porosyat molochnogo pitaniya, poluchavshih «Gamavit» / E.V. Krapivina, O.N. Makurina // Veterinariya, zootehniya i biotehnologiya. - 2016. - № 6. - S. 50-55.
14. Krapivina, E.V. Normalizaciya aktivnosti sistemy gemostaza u oslablennyh novorozhdennyh porosyat i telyat pri pomoschi biologicheskogo stimulyatora / E.V. Krapivina // Uchenye zapiski Kazanskoy GAVM im. N.E. Baumana. - 2019. - T. 239. - № 3. - S. 150-157. DOI:https://doi.org/10.31588/2413-4201-1883-239-3-150-158.
15. Medvedev, I.N. Vliyanie poliprenolov hvoi na gemostaz u novorozhdennyh telyat pri narushenii pischevareniya / I.N. Medvedev, T.A. Belova, S.Yu. Zavalishina, E.G. Krasnova //Veterinariya. - 2009. - № 8. - S. 49-51.
16. Nikulina, N.B. Nauchno-obosnovannye metody lecheniya i profilaktiki nespecificheskoy bronhopnevmonii telyat v permskom krae / N.B. Nikulina: avtoref. diss. … doktora veterinarnyh nauk. Zaschischena 7 dekabrya 2012 g.- Troick, FGBOU VPO «Ural'skaya gosudarstvennaya akademiya veterinarnoy mediciny». - g. Troick 2012. - 48 s.
17. Obryvin, V.N. Vliyanie preparatov gamavit i galavet na toksicheskiy immunodeficit u belyh krys / V.N. Obryvin, GA. Zhorov, P.N. Rubchenkov // Veterinarnaya patologiya. - 2008. - № 3. - S. 119-125.
18. Pereslegina, I.O. Korrekciya anemii pri gastroenterokolite u sobaki, vyzvannym hronicheskim otravleniem: klinicheskiy sluchay / I.O. Pereslegina // Veterinariya. - 2019. - № 1. - S. 51-53.
19. Pereslegina, I.O. Korrekciya poliorgannoy nedostatochnosti u koshki posle toksicheskoy peredozirovki narkoza / I.O. Pereslegina, S.E. Zhavnis // Veterinariya. - 2019. - № 5. - S. 46-50.
20. Pronin, A.V. Poliprenoly kak vozmozhnye faktory, opredelyayuschie instruktivnuyu rol' estestvennogo immuniteta v razvitii priobretennogo immunnogo otveta / A.V. Pronin, E.A. Grigor'eva, A.V. Sanin, A.N. Narovlyanskiy, S.V. Ozherelkov, A.V. Deeva, L.L. Danilov, S.D. Mal'cev, A. Nadzhid // Ross. immunol. Zhurnal. - 2002. - T. 7. - № 2. - S. 135-142.
21. Rostrosa, P.A. Povyshenie estestvennoy rezistentnosti i vyzhivaemosti norok pri neblagopoluchii po aleutskoy bolezni / P.A. Rostrosa, A.V. Sanin, A.N. Narovlyanskiy, A.V. Pronin, T.N. Kozhevnikova // Rossiyskiy veterinarnyy zhurnal. - 2019. - № 6 - S. 14-19.
22. Sanin, A.V. Sovremennye immunomodulyatory dlya krupnogo rogatogo skota / A.V. Sanin, A.A. Videnina, A.V. Deeva, A.N. Narovlyanskiy, A.V. Pronin // Veterinariya. - 2012. - № 11. - S. 9-12.
23. Sanin, A.V. Primenenie gamavita dlya stimulyacii produkcii somatotropnogo gormona v zhivotnovodstve / A.V. Sanin, A.V. Deeva, A.N. Narovlyanskiy, A.V. Pronin, A.V. Kudinov, D.A. Shirobokova, V.V. Annikov // Veterinariya. - 2013. - № 11. - S. 19-21.
24. Sanin, A.V. Izuchenie antioksidantnyh svoystv Fosprenila v razlichnyh biologicheskih test-sistemah / A.V. Sanin, A.N. Narovlyanskiy, A.V. Pronin, T.N. Kozhevnikova, V.Yu. Sanina, A.D. Agafonova // Rossiyskiy veterinarnyy zhurnal. MDZh. - 2017. - № 6. - S. 28-31.
25. Sanin, A.V. Gamavit dlya korrekcii toksicheskoy gemoliticheskoy anemii i stimulyacii eritropoeza / A.V. Sanin, A.N. Narovlyanskiy, A.V. Pronin, T.N. Kozhevnikova, O.Yu. Sosnovskaya, S.E. Zhavnis, S.V. Ozherelkov, D.A. Klimova // Veterinariya. - 2018. - № 10. - S. 54-59.
26. Sanin, A.V. Povyshenie sohrannosti, rosta, razvitiya i nespecificheskoy rezistentnosti telyat s pomosch'yu sovremennyh immunomoduliruyuschih sredstv / A.V. Sanin, S.L. Savoyskaya, T.N. Kozhevnikova, V.Yu. Sanina, O.Yu. Sosnovskaya // Veterinariya Kubani. - 2019. - № 2. - S. 11-14.
27. Sanin, A.V. Primenenie sovremennyh immunomoduliruyuschih i biostimuliruyuschih sredstv dlya korrekcii narusheniy gemostaza i povysheniya nespecificheskoy rezistentnosti u porosyat / A.V. Sanin, A.N. Narovlyanskiy, A.V. Pronin, V.Yu. Sanina, T.N. Kozhevnikova // Veterinariya Kubani. - 2019. - № 3. - S. 15-18.
28. Sviridova, S.P. Rol' trombocitov v vospalenii i immunitete / S.P. Sviridova, O.V. Somonova, Sh.R. Kashiya, O.A. Obuhova, A.V. Sotnikov // Issledovaniya i praktika v medicine. - 2018. - T. 5. - № 3. - S. 40-52.
29. Serebryanaya, N.B. Trombocity kak aktivatory i regulyatory vospalitel'nyh i immunnyh reakciy. Chast' 2. Trombocity kak uchastniki immunnyh reakciy / N.B. Serebryanaya, S.N. Shanin, E.E. Fomicheva, P.P. Yakuceni // Medicinskaya immunologiya. - 2019. - T. 21. - № 1. - C. 9-20.
30. Smolencev, S.Yu. Rezistentnost' u novorozhdennyh telyat pod vliyaniem «gamavita» / S.Yu. Smolencev // Vestnik Mariyskogo gosudarstvennogo universiteta. Seriya «Sel'skohozyaystvennye nauki. Ekonomicheskie nauki». - 2017. - T. 3. - № 1. - S. 70-74.
31. Sobeschanskaya, E.M. Vliyanie fitopreparata Fosprenil na funkcional'nuyu aktivnost' kletok krovi telyat novorozhdennogo perioda / E.M. Sobeschanskaya // Sel'skohozyaystvennye nauki i agropromyshlennyy kompleks na rubezhe vekov. - 2015. - № 10. - S. 155-159.
32. Topuriya, L.Yu. Biohimicheskiy sostav krovi telyat na fone primeneniya immunostimulyatora. / L.Yu. Topuriya, L.N. Trushina, D.V. Uhanova // Materialy Vserossiyskoy nauchno-prakticheskoy konferencii «Aktual'nye voprosy zooveterinarnoy nauki», Izhevsk, 15 maya 2019. - S. 85-89.
33. Tumilovich, G.A. Strukturnaya organizaciya slizistoy obolochki predzheludka telyat na fone primeneniya nizkointensivnogo lazernogo izlucheniya i preparata «Gamavit» / G.A. Tumilovich, D.N. Haritonik, A.V. Bashura // Zhivotnovodstvo i veterinarnaya medicina. - 2014. - № 3. - S. 40-47.
34. Uhanova, D.V. Morfologicheskiy sostav krovi telyat pri primenenii immunostimulyatora / D.V. Uhanova // Sbornik nauchnyh statey po materialam 84-y nauchno-prakticheskoy konferencii. - Stavropol', 17 maya 2019 g. - S. 229-232
35. Haitov, R.M. Immunologiya: struktura i funkciya immunnoy sistemy / R.M. Haitov. - M.: GEOTAR-Media, 2019. - 325s.
36. Barnett, K.C. Lipids that directly regulate innate immune signal transduction / K.C. Barnett, J.C. Kagan // Innate Immun. - 2020. - Vol. 26. - No. 1. - pp. 4-14. doi:https://doi.org/10.1177/1753425919852695
37. Cognasse, F. Evidence of Toll-like receptor molecules on human platelets / F. Cognasse, H. Hamzeh, P. Chavarin, S. Acquart, C. Genin, O. Garraud // Immunol. Cell. Biol. - 2005. - Vol. 83. - pp. 196-198.
38. Delvaeye, M. Coagulation and innate immune responses: can we view them separately? / M. Delvaeye, E.M. Conway // Blood. - 2009. - No. 114. - pp. 2367-2374.
39. Doni, A. Innate immunity, hemostasis and matrix remodeling: PTX3 as a link (Review) / A. Doni, C. Garlanda, A. Mantovani // Seminars in Immunology. - 2016 December. - Vol. 28. - Is. 6. - No. 1. - pp 570-577.
40. Esmon, C.T. Innate Immunity and Coagulation / C.T. Esmon, J. Xu, F. Lupu // Journal of Thrombosis and Haemostasis. - 2011. - Suppl 1(1). - pp. 182-188.
41. Garraud, O. Are platelets cells? And if yes, are they immune cells? / O. Garraud, F. Cognasse // Front. Immunol. - 2015 February. - No. 20. | https://doi.org/10.3389/fimmu.2015.00070
42. Gruber, E.J. Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling / E.J. Gruber, C.A. Leifer // Innate Immun. - 2020. - Vol. 26. - No. 1. - pp. 15-25 doi:https://doi.org/10.1177/1753425919838322
43. Kehrel, B. Platelets at the Interface between Hemostasis and Innate Immunity / B. Kehrel, K. Jurk // Transfus Med Hemother. - 2004. - No. 31. - pp. 379-386.
44. Keragala C.B., Haemostasis and innate immunity - a complementary relationship: a review of the intricate relationship between coagulation and complement pathways / C.B. Keragala, D. F. Draxler, Z.K. McQuilten, R.L. Medcalf // Br. J. Haematol. - 2018. - Vol. 180. - Is. 6. - pp. 782-798.
45. Leifer, C.A. Molecular mechanisms of regulation of Toll-like receptor signaling / C.A. Leifer, A.E. Medvedev // J Leukoc Biol. - 2016. - No. 100. - pp. 927-941.
46. Li, C. Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries / C. Li, J. Li, Y. Li, S. Lang, I. Yougbare, G. Zhu, P. Chen, H. Ni // Advances in Hematology. - 2012. - Article ID 384685, 14 p.
47. McDonald, D.R. Innate Immunity. In: Clinical Immunology (Fifth Edition) / D.R. McDonald, O. Levy // Principles and Practice. - 2019. - pp. 39-53. https://doi.org/10.1016/B978-0-7020-6896-6.00003-X
