EVALUATION OF A PREVENTIVE EFFICACY FOR A NEW ANTHELMINTHIC DRUG SUPRAMIL® TABLETS REGARDING HEARTWORM DISEASE IN DOGS
Abstract and keywords
Abstract (English):
There was studied an effectiveness of the new anthelmintic drug Supramil® tablets for prevention of dirofilariasis in dogs. With a monthly treatment of dogs free from larvae of Dirofilaria spp. with the drug Supramil® tablets, used at dose of 0.5 mg / kg on a body weight according to milbemycin oxime, in a region unfavorable for dirofilariasis, the preventive effectiveness of the drug was 100 %. Monthly control of microfilariaemia, carried out before each drug treatment, showed an absence of larvae of Dirofilaria spp. in peripheral blood of 100% of experimental animals, which indicates not only high preventive efficacy of the drug, but also its prolonged microfilaricidal action and a possibility to use it for prevention of dirofilariasis with an interval of 28…35 days. Thus, Supramil® tablets are highly effective to prevent dirofilariasis in disadvantaged regions.

Keywords:
efficacy, Supramil® tablets, prevention, dirofilariasis, heartworm disease, Dirofilaria spp., dogs, milbemycin oxime
Text
Publication text (PDF): Read Download
References

1. Arhipov, I.A. Dirofilyarioz: monografiya / I.A. Arhipov, D.R. Arhipova. - M.: Rossel'hozakademiya, 2004. - 194 s.

2. Arhipova, D.R. Biologiya dirofilyariy i epizootologiya dirofilyarioza sobak v stepnoy zone yuga Rossii: spec. 03.00.19 «Parazitologiya», 16.00.03 -«Veterinarnaya mikrobiologiya, virusologiya, epizootologiya, mikologiya s mikotoksikologiey i immunologiya»: avtoref. dis ... kand. biol. nauk / Arhipova Dina Ramil'evna. - N. Novgorod, 2003. - 25 s.

3. Bogdanova, T.V. Biologicheskie aspekty parazitirovaniya Dirofilaria immitis u sobak v Astrahanskoy oblasti: spec. 03.00.19 «Parazitologiya»: avtoref. dis. … kand. biol. nauk / Bogdanova Tat'yana Viktorovna. - Astrahan', 2010. - 27 s.

4. GOST R 58090-2018 Klinicheskoe obsledovanie neproduktivnyh zhivotnyh. Obschie trebovaniya: data vvedeniya 2018-10-01. - Moskva: Standartinform, 2018. - 12 s.

5. Zolotyh, T.A. Dirofilyarioz domashnih plotoyadnyh Voronezhskoy oblasti (rasprostranenie, kliniko-gematologicheskaya harakteristika, mery bor'by i profilaktiki): spec. 03.02.11 «Parazitologiya»: diss. ... kand. vet. nauk / Zolotyh Tat'yana Alekseevna; Voronezh, 2017 - 125 s.

6. Konyaev, S.V. Rasprostranenie Dirofilaria immitis v stranah byvshego SSSR. / S.V. Konyaev // Sovremennaya veterinarnaya medicina. - 2019. - № 5. - S. 26-41.

7. Morozova, L.F. Dirofilyariozy: klinicheskaya kartina, diagnostika, lechenie, profilaktika / L.F. Morozova, E.O. Tihonova, M.A. Zotova [i dr.] // Infekcionnye bolezni: novosti, mneniya, obuchenie. - 2018. - T. 7. - № 4. - S. 90-96.

8. Orobec, V.A. Ocenka terapevticheskoy effektivnosti suspenzii Prazitel® Osobyy pri kishechnyh gel'mintozah schenkov i kotyat / V.A. Orobec, O.I. Sevost'yanova, I.V. Zaichenko, S.V. Mukaseev // Rossiyskiy veterinarnyy zhurnal. - 2019. - №7 - S. 25-32.

9. Orobec, V.A. Toksikologicheskaya ocenka antigel'mintnogo preparata Supramil® tabletki dlya sobak i koshek / V.A. Orobec, S.V. Mukaseev. O.A. Zeynalov // Veterinariya. - 2022. - №6. - S. 55-62.

10. Orobec, V.A. Effektivnost' novogo antigel'mintnogo preparata Supramil® tabletki pri kishechnyh gel'mintozah sobak i koshek / V.A. Orobec, O.I. Sevost'yanova, I.V. Zaichenko, S.V. Mukaseev, O.A. Zeynalov // Rossiyskiy veterinarnyy zhurnal. - 2022. - № 2. S. 30-41.

11. Orobec, V.A. Effektivnost' novogo antigel'mintnogo preparata Prazitel® Osobyy pri lechenii kishechnyh gel'mintozov sobak starshe 6 let / V.A. Orobec, O.I. Sevost'yanova, I.V. Zaichenko, S.V. Mukaseev // Rossiyskiy veterinarnyy zhurnal. - 2018. - № 2. - S. 45-48.

12. Patent RU 2613490 C2. Kompoziciya na osnove R(-)-prazikvantela dlya lecheniya i profilaktiki gel'mintozov u teplokrovnyh. Vladelec patenta: Obschestvo s ogranichennoy otvetstvennost'yu «Nauchno-proizvodstvennaya kompaniya «SKiFF». Avtor: Zolotareva Vera Anatol'evna. Nachalo deystviya: 2015.01.27. Publikaciya: 2017.03.16. Podacha: 2015.01.27.

13. Patent RU 2722272 C1. Sredstvo dlya lecheniya i profilaktiki nematodozov i cestodozov u melkih domashnih zhivotnyh Vladelec patenta: Obschestvo s ogranichennoy otvetstvennost'yu «Nauchno-proizvodstvennaya kompaniya «SKiFF». Avtory: Kokorina Lyubov' Mihaylovna, Zeynalov Orhan Ahmed ogly. Nachalo deystviya: 2019.04.30. Publikaciya: 2020.05.28. Podacha: 2019.04.30.

14. Prazitel Osobyy. Unikal'noe reshenie dlya profilaktiki i lecheniya gel'mintozov u koshek i sobak starshe 6 let. - VetPharma. - 2017. - №3 (37). - S. 20-27.

15. Sogrina, A.V. Dirofilyarioz sluzhebnyh sobak v Permskom krae (rasprostranenie, serologicheskiy monitoring, kariopaticheskoe deystvie antigenov Dirofilaria immitis i protivoparazitarnyh preparatov): spec. 03.02.11 «Parazitologiya»: diss. ... kand. biol. nauk / Sogrina Anastasiya Viktorovna. - Moskva, 2017 - 147 s.

16. Supryaga, V.G. Izuchenie dirofilyarioza v Rossii / V.G. Supryaga, T.V. Starkova, T.P. Sabgayda [i dr.] // Osnovnye dostizheniya i perspektivy razvitiya parazitologii. - M., 2004. - S. 304-306.

17. Shinkarenko, A.N. Ekologiya dirofilyarioza sobak i morfofunkcional'naya dinamika ego oslozhneniya tromboemboliey legochnoy arterii / A.N. Shinkarenko, P.V. Kolesnikov // Vestnik Volgogradskogo gosudarstvennogo universiteta. - 2009. - №2. - S. 244-248.

18. Shulyak, B.F. Nematodozy sobak (zoonozy i antropozoonozy) / B.F. Shulyak, I.A. Arhipov. - Moskva: KonsoMed, 2010. - 495 s.

19. Yastreb, V.B. Gel'mintozoonozy: ehinokokkoz i dirofilyarioz (biomorfologicheskie osobennosti vozbuditeley, sovershenstvovanie mer bor'by): spec. 03.00.19 «Parazitologiya»: avtoref. dis. … dokt. vet. nauk / Yastreb Valeriy Bronislavovich. - M., 2009. - 48 s.

20. Yastreb, V.B. Dirofilyarioz sobak i cheloveka v Moskovskom regione / V.B. Yastreb // Shnaucer segodnya. - 2006. - № 2. - S. 23-25.

21. Yastreb, V.B. Rekomendacii po diagnostike, lecheniyu i profilaktike dirofilyarioza sobak v Moskovskom regione / V.B. Yastreb, I.A. Arhipov // Rossiyskiy parazitologicheskiy zhurnal. - 2008. - № 4. - S. 109-114.

22. Andrews, P., Praziquantel / P. Andrews, H. Thomas, R. Pohlke, J. Seubert // Med. Res. Rev. - 1983. - No. 3. - pp. 147-200.

23. Cioli, D. Schistosomiasis control: Praziquantel forever? / D. Cioli, L. Pica-Mattoccia, A. Basso, A. Guidi // Mol Biochem Parasitol. - 2014. - No. 195(1). - pp. 23-29.

24. Meister, I. Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni / I. Meister, K. Ingram-Sieber, N. Cowan, M. Todd, M.N. Robertson, C. Meli, M. Patra, G. Gasser, J. Keiser // Antimicrob Agents Chemother. - 2014. - Sep 30, - No. 58(9). - pp. 5466-5472.

25. Meyer, T. Taste, a new incentive to switch to (R)-Praziquantel in schistosomiasis treatment / T. Meyer, H. Sekljic, S. Fuchs, H. Bothe, D. Schollmeyer, C. Miculka // PLoS Negl. Trop. Dis. - 2009. - No. 3, - r. 357.

26. Olliaro, P. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer) / P. Olliaro, P. Delgado-Romero, J. Keiser // J. Antimicrob. Chemother. - 2014. - No. 69(4). - rr. 863-870.

27. Shuhua, X. Tegumental changes in adult Schistosoma mansoni harboured in mice treated with praziquantel enantiomers / X. Shuhua, S. Binggui, J. Chollet, M. Tanner // Acta Trop. - 2000. - Sep 18. - No. 76(2). - pp. 107-117.

28. Wu, M.H. Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica / M.H. Wu, C.C. Wei, Z.Y. Xu, H.C. Yuan, W.N. Lian, Q.J. Yang, M. Chen, Q.W. Jiang, C.Z. Wang, S.J. Zhang et al. // Am. J. Trop. Med. Hyg. - 2000. - No. 45. - rr. 345-349.

29. Xiao, S. Scanning electron microscope observation on tegumental alteration of Schistosoma japonicum induced by levo- and dextro-praziquantel. Institute of Parasitic Diseases / S. Xiao, B. Shen // Chinese Academy of Preventive Medicine, Shanghai. - 1995. - No. 13(1). - pp. 46-50.

Login or Create
* Forgot password?