LLC «AG «Aspect» (Veterinarian)
LLC «RDE «Astrapharm» (Leading veterinarian)
Russian Federation
LLC «RDE «Astrapharm» (Chief science specialist)
Russian Federation
GRNTI 68.41 Ветеринария
In an experiment on 30 dogs and 30 cats of different ages, the effect of the drug Supramil® tablets in twice and three times increased doses on the clinical condition, morphological and biochemical parameters of blood was studied. The drug was administered to dogs and puppies individually orally in two-fold (5.0 mg/ kg for R-praziquantel and 1.0 mg / kg for milbemycin oxime) and three-fold (7.5 mg / kg for R-praziquantel and 1.5 mg / kg for milbemycin oxime) therapeutic doses daily for 7 days with an interval of 24 hours. The drug was administered individually to cats and kittens orally in two-fold (5.0 mg/ kg for R-praziquantel and 4.0 mg/ kg for milbemycin oxime) and three-fold (7.5 mg/ kg for R-praziquantel and 6.0 mg/kg for milbemycin oxime) therapeutic doses daily for 7 days with an interval of 24 hours. During the entire study period, the clinical condition of the animals and their behavior were monitored. Before administration of the drug, on the 8th and 15th days after the last administration, blood samples were taken for cbc and biochemical blood test. The results of observations of the clinical condition and behavior of the target animals, data on the determination of clinical and hematological parameters indicate good tolerability of the drug in high doses.
Supramil® tablets, R-praziquantel, milbemycin oxime, tolerability, dogs, puppies, cats, kittens, clinical parameters, cbc blood test, biochemical blood test, safety
1. Vasilevich. F.I., Invazionnye bolezni i parazity plotoyadnyh zhivotnyh: monografiya / F.I. Vasilevich, N.V. Esaulova, R.M. Akbaev. - M.: ZooVetKniga, 2019. - 314 s.
2. Zaichenko, I.V. Gel'mintozy plotoyadnyh gorodskoy populyacii: rasprostranenie, diagnostika, lechenie: avtoref. diss. ... kand. vet. nauk / I.V. Zaichenko. - Stavropol', 2012. - 20 s.
3. Konyaev, S.V. Rasprostranenie Dirofilaria immitis v stranah byvshego SSSR. / S.V. Konyaev // Sovremennaya veterinarnaya medicina. - 2019. - №5. - S. 26-41.
4. Orobec, V.A. Effektivnost' novogo antigel'mintnogo preparata Prazitel® Osobyy pri lechenii kishechnyh gel'mintozov sobak starshe 6 let / V.A. Orobec, O.I. Sevost'yanova, I.V. Zaichenko, S.V. Mukaseev // Rossiyskiy veterinarnyy zhurnal. - 2018. - №2. - S. 45-48.
5. Orobec, V.A. Ocenka terapevticheskoy effektivnosti suspenzii Prazitel® Osobyy pri kishechnyh gel'mintozah schenkov i kotyat / V.A. Orobec, O.I. Sevost'yanova, I.V. Zaichenko, S.V. Mukaseev // Rossiyskiy veterinarnyy zhurnal. - 2019. - № 7 - S. 25-32.
6. Orobec, V.A. Toksikologicheskaya ocenka antigel'mintnogo preparata dlya sobak i koshek Supramil® tabletki / V.A. Orobec, S.V. Mukaseev. O.A. Zeynalov // Veterinariya. - 2022. - №6 - S. 55-63.
7. Patent RU 2613490 C2. Kompoziciya na osnove R(-)-prazikvantela dlya lecheniya i profilaktiki gel'mintozov u teplokrovnyh. Vladelec patenta: Obschestvo s ogranichennoy otvetstvennost'yu «Nauchno-proizvodstvennaya kompaniya «SKiFF». Avtor: Zolotareva Vera Anatol'evna. Nachalo deystviya: 2015.01.27. Publikaciya: 2017.03.16. Podacha: 2015.01.27
8. Patent RU 2722272 C1. Sredstvo dlya lecheniya i profilaktiki nematodozov i cestodozov u melkih domashnih zhivotnyh Vladelec patenta: Obschestvo s ogranichennoy otvetstvennost'yu «Nauchno-proizvodstvennaya kompaniya «SKiFF». Avtory: Kokorina Lyubov' Mihaylovna, Zeynalov Orhan Ahmed ogly. Nachalo deystviya: 2019.04.30. Publikaciya: 2020.05.28. Podacha: 2019.04.30.
9. Peshkov, R.A. Epizootologicheskiy analiz toksokaroza plotoyadnyh i gel'mintologicheskaya ocenka vneshney sredy v megapolise Moskvy: avtoref. dis. ... kand. vet. Nauk / R.A. Peshkov. - M., 2010. - 23 s.
10. Prazitel Osobyy. Unikal'noe reshenie dlya profilaktiki i lecheniya gel'mintozov u koshek i sobak starshe 6 let // VetPharma. - 2017. - №3 (37). - S. 20-27.
11. Fadeeva, A.N. Parazitarnye bolezni domashnih plotoyadnyh v usloviyah Nizhnego Novgoroda / A.N. Fadeeva, N.G. Gorchakova // Veterinariya. - 2016. - №.6. - S. 33-35.
12. Andrews, P. Praziquantel / P. Andrews, H. Thomas, R. Pohlke, J. Seubert // Med. Res. Rev. - 1983. - No. 3. - pp. 147-200.
13. Cioli, D. Schistosomiasis control: Praziquantel forever? / D. Cioli, L. Pica-Mattoccia, A. Basso, A. Guidi // Mol Biochem Parasitol. - 2014. - No. 195(1). - pp. 23-29.
14. Liu, Y.H. Levo-praziquantel versus praziquantel in experimental and clinical treatment of schistosomiasis japonica / Y.H. Liu, M.X. Qian, X.G. Wang, et al. // Chin. Med. J. (Engl). - 1993. - No. 106. - rr. 593-596.
15. Meister, I. Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni / I. Meister, K. Ingram-Sieber, N. Cowan, M. Todd, M.N. Robertson, C. Meli, M. Patra, G. Gasser, J. Keiser // J. Antimicrob Agents Chemother. - 2014 Sep 30. - No. 58(9). - pp. 5466-5472.
16. Meyer, T. A new incentive to switch to (R)-Praziquantel in schistosomiasis treatment / T. Meyer, H. Sekljic, S. Fuchs, H. Bothe, D. Schollmeyer, C. Miculka, Taste A. // PLoS Negl. Trop. Dis. - 2009. - No. 3. - rp. 357.
17. Olliaro, P. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer) / P. Olliaro, P. Delgado-Romero, J. Keiser // J. Antimicrob. Agents Chemother. - 2014. - No. 69(4). - rr. 863-870.
18. Shuhua, X. Tegumental changes in adult Schistosoma mansoni harboured in mice treated with praziquantel enantiomers / X. Shuhua, S. Binggui, J. Chollet, M. Tanner // Acta Trop. - 2000 Sep 18. - No. 76(2). - pp, 107-117.
19. Tanaka, M. A comparison of the antischistosomal effect of levo- and dextro-praziquantel on Schistosoma japonicum and S. mansoni in mice / M. Tanaka, H. Ohmae, H. Utsunomiya, T. Nara, Y. Irie, K. Yasuraoka // Am. J. Trop. Med. Hyg. - 1989. - No. 41. - rr. 198-203.
20. Wu, M.H. Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica / M.H. Wu, C.C. Wei, Z.Y. Xu, H.C. Yuan, W.N. Lian, Q.J. Yang, M. Chen, Q.W. Jiang, C.Z. Wang, S.J. Zhang et al. // Am. J. Trop. Med. Hyg. - 2000. - No. 45. - rr. 345-349.
21. Xiao, S. Scanning electron microscope observation on tegumental alteration of Schistosoma japonicum induced by levo- and dextro-praziquantel / S. Xiao, B. Shen // Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. - 1995. - No. 13(1). - rr. 46-50.
