employee
LLC AG Aspect (Scientific consultant)
employee
LLC «RDE «Astrapharm» (Scientific consultant)
employee
Russian Federation
employee
Russian Federation
employee
LLC «AG «Aspect» (Veterinarian)
employee
LLC «RDE «Astrapharm» (Leading veterinarian)
employee
Russian Federation
GRNTI 68.41 Ветеринария
The results presented in this work allows us to conclude that daily use of the drug Kurs Uspokoin tablets based on trazodone succinate in dogs in high doses for 54 weeks is safe.
trazodone succinate, Kurs Uspokoyin tablets, dogs, chronical toxicity, tolerability, safety
1. Thalmann O., Shapiro B., Cui P., Schuenemann V.J., Sawyer S.K., Greenfield D., et al. Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs, Science, 2013, No. 342, pp. 871-4. doi:https://doi.org/10.1126/science.1243650
2. Payne E., Bennett P.C., Mcgreevy P.D., Current perspectives on attachment and bonding in the dog-human dyad, Psychol Res Behav Manag., 2015, No. 8, pp. 71. doi:https://doi.org/10.2147/PRBM.S74972
3. Alcántara-López M.G., Gutiérrez-García A.G., Hernández- Lozano M., Contreras C.M., Trazodone, an atypical antidepressant with anxiolytic and sedative properties, Arch Neurocien, 2009, No. 14 (4), pp. 249-257.
4. Cuomo A, Bianchetti A., Cagnin A., Trazodone: a multifunctional antidepressant. Evaluation of its properties and real-world use, Journal of Gerontology and Geriatrics, 2021 June, Vol. 69, Is. 2, pp. 2-7.
5. Haria M., Fitton A., McTavish D., Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders. Drugs Aging., 1994, No. 4(4), pp. 331.
6. Stahl S.M., Mechanism of Action of Trazodone: a Multifunctional Drug. CNS Spectrums, Volume 14, October 2009, pp. 536-546 DOI: https://doi.org/10.1017/S1092852900024020
7. Foss T., Trazodone in Veterinary Medicine, URL: https://todaysveterinarynurse.com/articles/trazodone-in-veterinarymedicine/ (date of access: 14.10.2021).
8. Trazodone in Veterinary Medicine. https://todaysveterinarynurse.com/toxicology/trazodone-in-veterinary-medicine/
9. Lueck L.C, Cameron S., Zidan N., Effects of trazodone administration on the neurologic examination in healthy dogs, J Vet Intern Med., 2022 Nov-Dec, No. 36(6), pp. 2142-2148.
10. Beloglazov D.V., Mukaseev S.V., Zeinalov O.A. Trazodone succinate - new opportunities for pharmacological correction of situational behavioral abnormalities in dogs and cats, Rossijskij veterinarnyj zhurnal, 2021, No. 4, pp. 5-13. DOIhttps://doi.org/10.32416/2500-4379-2021-4-5-13 (In russ.).
11. Orobets V.A., Beloglazov D.V., Mukaseev S.V., Zeinalov O.A., Toxicological characteristics of a new drug Express Uspokoin® tablets for situational correction of behavioral abnormalities in cats and dogs, Rossijskij veterinarnyj zhurnal, 2023, No. 1, pp. 10-18. DOIhttps://doi.org/10.32416/2500-4379-2023-1-10-18 (In russ.).
12. Beloglazov D.V., Mukaseev S.V., Zeinalov O.A., Evaluation of the effectiveness of the new drug Express Uspokoyin® tablets in the situational correction of behavioral problems in dogs, Sovremennaya veterinarnaya medicina, 2023., No. 1, pp.18-22. (In russ).
13. Beloglazov D.V., Mukaseev S.V., Zeinalov O.A., Evaluation of the effectiveness of the new drug Express Uspokoyin® tablets in the situational correction of behavioral problems in cats, Rossijskij veterinarnyj zhurnal, 2023, No. 2, pp. 14-22. DOIhttps://doi.org/10.32416/2500-4379-2023-2-14-22 (In russ.).
14. Balsara J.J., Jadhav S.A., Gaonkar K.A., Gaikwad R.V., Jadhav J.H., Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats, Psychopharmacology, 2005, No. 179, pp. 597-605.
15. Danilov D.S., Multimodal serotonergic antidepressants, Zhurnal nevrologii i psixiatrii, 2017, No. 9, pp. 103-111.
16. Goldberg J.F., Steinman M.Q, Stephen M. Stahl S.M., Trazodone once-a-day: A formula for addressing challenges in antidepressant safety and tolerability, Neuroscience Applied 2023, Vol. 2, pp. 2.
17. Ghanbari R, Mansari M.E., Blier P. Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain, European Neuropsychopharmacology, July 2012, Vol. 22, Is. 7, pp. 518-526
18. Patent RU2792666C1, 08.12.2022. Course use of trazodone succinate for the treatment of cognitive dysfunction in elderly dogs and cats. Russian patent for IPC A61K31/496 A61P25/20 A61P25/28. Zeynalov Orhan Ahmed Oglu. (In Russ.)
19. Odagaki Y., Toyoshima R., Yamauchi T., Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S] GTPgammaS binding, J Psychopharmacol. 2005 May, No. 19(3), pp. 235-41.
20. Meulman J., Visacri M.B., Influence of Genetic Polymorphisms on the Pharmacokinetics of Trazodone Hydrochloride: A Scoping Review and Future Perspective, Therapeutic Drug Monitoring, 2023 August, No. 45(4), pp. 479-486, DOI:https://doi.org/10.1097/FTD.0000000000001049
21. Settimo L., Taylor D., Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets. Journal of Psychopharmacology, 2018, No. 32(1), pp. 96-104.
22. Ratio-Trazodone. URL: https://pdf.hres.ca/dpd_pm/00020887.PDF
