Abstract and keywords
Abstract (English):
Dexmedetomidine is a selective alpha2-adrenoreceptor agonist with a powerful sedative effect and analgesic properties. High selectivity of dexmedetomidine (1620:1) makes it the optimal drug among all representatives of the alpha-2adrenoreceptor agonist class for use in relatively small animals. Dexmedetomidine is currently the most popular sedative used for premedication and sedation, as well as in multimodal analgesia in a constant-rate infusion mode in intensive care. In 2024, a domestic drug with the trade name «Dexody» of the pharmaceutical company «Apicenna» with the active substance dexmedetomidine was registered. The drug is a complete analogue of the original drug and is approved for use in veterinary medicine.

Keywords:
selective alpha2-adrenoreceptor agonists, dexmedetomidine, premedication, sedation, multimodal analgesia, Dexodyia
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References

1. Kornyushenkov, E.A. Obschie voprosy anesteziologii i intensivnoy terapii melkih domashnih zhivotnyh: uchebnoe posobie / E.A. Kornyushenkov. ‒ M.: Sam Poligrafist, 2018. ‒ S. 147-155

2. Gimel'farb, A.I. Al'fa-2agonisty v veterinarnoy anestezii: starye istiny, novye dannye, vozmozhnye perspektivy / A.I. Gimel'farb, E.A. Kornyushenkov, N.V. Danilevskaya, D.A. Evdokimov // Rossiyskiy veterinarnyy zhurnal. Melkie domashnie zhivotnye. ‒ 2011. ‒ № 2. ‒ S. 42-45.

3. Campagnol, D. Effects of epidural administration of dexmedetomidine on the minimum alveolar concentration of isoflurane in dogs / D. Campagnol, N. Teixeira, T. Giordano, et al. // Am J Vet Res. ‒ 2007. ‒ No. 68 (12). ‒ pp. 1308-1318.

4. Hammond, R.A. The effect of dexmedetomidine premedication upon propofol induction and infusion anaesthesia in the dog / R.A. Hammond, England G.C.W. // Vet Anaest Analg, ‒ July 1998. ‒ Vol 21. ‒ Is. 1. ‒ pp. 24-28.

5. Kuo, W.-C. Comparative cardiovascular, analgesic, and sedative effects of dexmedetomidine, dexmedetomidine-hydromorphone, and dexmedetomidine-butorphanol in dogs / W.-C. Kuo, R.D. Keegan // Am J Vet Res, July 2004. ‒ Vol. 65. ‒ No. 7. ‒ pp. 931-937.

6. Moens, Y. A comparative study of medetomidine/ketamine and xylazine/ketamine anaesthesia in dogs / Y. Moens, X. Fargetton // Vet Rec. ‒ 1990 December 8. ‒ No. 127. ‒ pp. 567-571.

7. Pascoe, P.J. Use of opioids and alha-2 agonists in geriatric patients / P.J. Pascoe // The proceeding of AVA Spring Meeting, March 2009, Helsinki.

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