GRNTI 68.41 Ветеринария
Urolithiasis is a common clinical problem in dogs. Struvite and calcium oxalate are the predominant mineral types in dog urolithiasis. The aim of the present study was to compare the effect of two commercial dry foods formulated for the management of struvite urolithiasis with different anion-cation balance on urinary pH. For the trial, twelve privately owned adult dogs showing struvite urolithiasis were studied. The dogs were randomly divided into two groups (A and B) and fed two dissolving diets for 3 months. The analyses of urine were repeated six times. In both diets, the anion-cation balance was negative (2203 and 2192 for diets A and B, respectively). At the first urine analysis, pH values of all the dogs were close to 8.0, and bacteria were present in about 70 % of the samples and thus an antimicrobial was administered for 1 week. Both groups showed a progressive decrease in pH values, and after 2 months, in both cases, the recommended pH values for stone dissolution were achieved. From the sampling at 30 d, group A showed pH values significantly (P < 0,05) lower than group B, probably due to the lower anion-cation balance of diet A. The combination of antimicrobial and dietary therapy allowed the dissolution of struvite uroliths in both groups, even if the utilisation of the diet characterised by the lower anion–cation balance seems to decrease the urinary pH more rapidly. In this case, it seems necessary to interrupt the dietary treatment in order to avoid the risk of other diseases.
urolithiasis, struvite, dogs, anion-cation balance
1. Stevenson A., Rutgers C., Nutritional management of canine urolithiasis. In Encyclopaedia of Canine Clinical Nutrition, [P Pibot, V Biourge and D Elliott, editors]. Aimargues: Aniwa SAS, 2006, pp. 285–315
2. Osborne C.A., Lulich J.P., Polzin D.J., et al., Analysis of 77,000 canine uroliths. Perspectives from the Minnesota Urolith Center, Vet Clin North Am Small Anim Pract, 1999, No. 29, pp. 17-35.
3. Picavet P., Detilleux J., Verschuren S., et al., Analysis of 4495 canine and feline uroliths in the Benelux. A retrospective study: 1994–2004, J Anim Physiol Anim Nutr (Berl), 2007, No. 91, pp. 247-251.
4. AOAC Official Methods of Analysis. Arlington, VA: Association of Official Analytical Chemists, 2006.
5. de Ruig W.G., Atomic Absorption Spectrometric determination of calcium, copper, iron, magnesium, manganese, potassium, sodium and zinc in animal feeding stuffs: interlaboratory collaborative studies, J Assoc Off Anal Chem, 1986, No. 69, pp. 1009-1013.
6. Langendorf H., Sa¨ure-Basen-Gleichgewicht und chronische acidogene und alkalogene Erna¨hrung (Acid–base balance and chronic acidogenic and alkalogene nutrition). In Zeitschrift fu¨r Erna¨hrungswissenschaft (Journal of Nutrition Science), [K Lang, editor], Mainz, 1963, pp. 1-76.
7. SAS User’s Guide Statistics version 8.2. Cary, NC: SAS Institute, Inc., 2000.
8. Lulich J.P., Osborne C.A., Bartges J.W., et al. Canine lower urinary tract disorders. In Textbook of Veterinary Internal Medicine – Diseases of the Dog and Cat, 5th ed., [S.J. Ettinger and E.C. Feldman, editors]. Philadelphia, PA: WB Saunders Company, 2000, pp. 1747-1781.
9. Commission Directive 2008/38/EC of 5 March 2008. Establishing a list of intended uses of animal feedingstuffs for particular nutritional purposes. EN – 20.08.2008.
10. Kienzle E., Wilms-Eilers S., Struvite diet in cats: effect of ammonium chloride and carbonates on acid base balance of cats, J Nutr, 1994, No. 124, pp. 2652S-2659S.
11. Osborne C.A., Lulich J.P., Polzin D.J., et al. Medical dissolution and prevention of canine struvite urolithiasis, Vet Clin North Am Small Anim Pract, 1999, No. 29, pp. 17-38.
12. Rinkardt N.E., Houston D.M. Dissolution of infection-induced struvite bladder stones using a non-calculolytic diet and antibiotic therapy, Can Vet J, 2004,