NUST MISIS (cientific and educational laboratory of tissue engineering and regenerative medicine, Professor)
employee
Russian Federation
Veterinary clinic «Biocontrol» (Head Physician)
Russian veterinary society of anesthesiologists «ANO VITAR» (President)
Veterinary Oncology Research Center «Biocontrol» (Chief Physician)
employee
Russian Federation
Veterinary Oncology Research Center «Biocontrol» (Leading Surgion)
employee
Russian Federation
employee
Russian Federation
employee
Russian Federation
employee
Russian Federation
student
Russian Federation
employee
Russian Federation
employee
Russian Federation
employee
NUST MISIS (Scientific and educational laboratory of tissue engineering and regenerative medicine, Professor)
employee
Russian Federation
68.41
Development of effective structures for joint arthrodesis remains an urgent task of modern medicine. To create such a structure, it is proposed to use bioresorbable composite materials based on polylactide with hydroxyapatite or silicon dioxide with a shape-memory effect. It was shown that such materials, in contrast to pure polylactide, have improved mechanical properties close to the characteristics of bone tissue. They are biocompatible, stimulate the adhesion of multipotent mesenchymal stromal cells and osteogenic differentiation in vitro. The composite materials based on polylactide are promising for the manufacture of customized and standardized constructs for arthrodesis using 3D-printing. It is expected that the shape-memory effect of the materials will simplify the installation of the construct, accelerate its fixation in bone defect ensuring the effectiveness of arthrodesis and recovery of the load-bearing capacity of the limb.
bioengineering design, polylactide, arthrodesis, shape memory effect, cell adhesion
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