MODERN ASPECTS OF DIAGNOSIS AND TREATMENT OF BIPOLAR AFFECTIVE DISORDER
Rubrics: PSYCHIATRY
Abstract and keywords
Abstract (English):
The paper analyzes the current scientific literature, including the results of clinical trials, meta-analyses and guidelines for the treatment of bipolar affective disorder (BAD) published in recent years. Modern diagnostic criteria, used scales for assessing the condition, as well as differential diagnosis with other mental disorders are considered. Modern hypotheses of the development of this disease, including genetic, biochemical and perinatal, are discussed. An overview of modern pharmacotherapy strategies for BAD is presented, including the use of mood stabilizers (lithium, valproates, carbamazepine), atypical antipsychotics, and antidepressants. The principles of individual selection of drug therapy, monitoring of side effects and prevention of relapses are described. The role of psychotherapy, in particular family-oriented therapy in the complex treatment of BAD is considered.

Keywords:
bipolar affective disorder, manic episode, depressive episode, diagnosis, pharmacotherapy, clinical manifestations, psychiatry, psychotherapy, family-oriented therapy
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References

1. Bipolyarnoe affektivnoe rasstroystvo: Klinicheskie rekomendacii. Rossiyskoe obschestvo psihiatrov, - 2021.

2. Arnold I, Dehning J, Grunze A, Hausmann A. Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment. Medicina (Kaunas). 2021 Jun 8;57(6):587. doi:https://doi.org/10.3390/medicina57060587. PMID: 34201098; PMCID: PMC8226928.

3. Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) / American Psychiatric Association, ed. 5th ed., rev. Washington, American Psychiatric Association Publ., 2022.

4. Joslyn C, Hawes DJ, Hunt C, Mitchell PB. Is age of onset associated with severity, prognosis, and clinical features in bipolar disorder? A meta-analytic reviewBipolar Disord. 2016; 18: 389-403.

5. Kamyar Keramatian, Nellai K Chithra, Lakshmi N Yatham Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults. PMID: 38711351 PMCID: PMC11351064

6. Keramatian K , Pinto JV , Schaffer A , et al. : Clinical and demographic factors associated with delayed diagnosis of bipolar disorder: data from Health Outcomes and Patient Evaluations in Bipolar Disorder (HOPE-BD) study . J Affect Disord 2022. ; 296 : 506 – 513

7. Miklowitz DJ, Chung B. Family-focused therapy for bipolar disorder: reflections on 30 years of research. Fam Process. 2016; 55: 483-99.

8. Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Bond DJ, Frey BN, Sharma V, Goldstein BI, Rej S, Beaulieu S, Alda M, MacQueen G, Milev RV, Ravindran A, O'Donovan C, McIntosh D, Lam RW, Vazquez G, Kapczinski F, McIntyre RS, Kozicky J, Kanba S, Lafer B, Suppes T, Calabrese JR, Vieta E, Malhi G, Post RM, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018 Mar;20(2):97-170. doi:https://doi.org/10.1111/bdi.12609. Epub 2018 Mar 14. PMID: 29536616; PMCID: PMC5947163.

9. Axelson D, Goldstein B, Goldstein T, Monk K, Yu H, Hickey MB, et al. Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal Study. Am J Psychiatry. 2015;172(7):638-646. doihttps://doi.org/10.1176/appi.ajp.2014.14010035.

10. Frey BN, Andreazza AC, Houenou J, Jamain S, Goldstein BI, Frye MA, et al. Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. Aust N Z J Psychiatry. 2013;47(4):32132. doihttps://doi.org/10.1177/0004867413478217.

11. The Columbia Bipolar Genetic Study. Bipolar disorder and genetics. Available at http://bipolar.hs.columbia.edu/disgenet.htm. Accessed: March 13, 2013.

12. Mohamed, M.A., Elhelbawy, A., Khalid, M. et al. Effects of bipolar disorder on maternal and fetal health during pregnancy: a systematic review. BMC Pregnancy Childbirth 23, 617 (2023).

13. Zila Martinez-Lozada, Children’s Hospital of Philadelphia, United States Axel Hutt, Inria Nancy - Grand-Est Research Centre, France. Glutamate: The Master Neurotransmitter and Its Implications in Chronic Stress and Mood Disorders: systematic review 2023. 15:722323. doi:https://doi.org/10.3389/fnhum.2021.722323

14. Phillips ML, Kupfer DJ. Bipolar disorder diagnosis: challenges and future directions. Lancet. 2013; 381: 1663-1671.

15. Dome P, Rihmer Z, Gonda X. Suicide Risk in Bipolar Disorder: A Brief Review. Medicina (Kaunas). 2019; 55: 403.

16. Parial S. Bipolar disorder in women. Indian J Psychiatry. 2015; 57(Suppl 2): S252-263.

17. Kaplan & Sadock's. Synopsis of Psychiatry. Copyright. 2022. Wolters Kluwer.

18. Folnegović Šmalc V, Štrkalj Ivezić S, Bagarić A, Mimica N. Classification and diagnosis of bipolar affective disorder. MEDIX. 2008; 77: 13–18.

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