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CSCSTI 68.41
Objectives: To evaluate the influence of two feline calculolytic diets on selected parameters of mineral metabolism. Materials and methods: Two dry commercial diets designed for struvite urolith dissolution were evaluated in 14 cats. The study was designed as a two-sequence, four-period crossover protocol with a baseline period, two 60-day «run-in» periods in which calculolytic diets (Diet 1 and Diet 2) were fed and one 30-day «wash-out» period. Data are expressed as median (range). Results: Feeding the calculolytic diets for two months did not alter plasma concentrations of calcium, phosphorus, magnesium and parathyroid hormone. A significant (P<0·05 in each case) decline in calcitriol was observed after administering both diets from 236·4 (122·4–429·6) to 170·4 (108·0–394·3) pmol/L (Diet 1) and from 278·4 (153·6–492·0) to 177·1 (87·6–392·4) pmol/L (Diet 2). Cats fed Diet 1 showed a significant increase in urine calcium concentration (from 0·3 (0·2–0·5) to 0·4 (0·3–0·7) mmol/L). Magnesium concentration in urine was significantly increased with both diets, from 1·4 (0·1–1·7) to 1·5 (1·3–2·4) mmol/L (Diet 1) and from 1·1 (0·4–1·9) to 2·0 (0·1–3·1) mmol/L (Diet 2). Clinical significance: Both diets resulted in an increased urinary concentration of magnesium, through different mechanisms: urine acidification (Diet 1) and increased sodium load (Diet 2).
cats, diet, mineral metabolism, stone dissolution
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