Moscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K.I. Scrjabin (Professor)
Stavropol', Stavropol, Russian Federation
Russian Federation
Peoples’ Friendship University of Russia named after Patrice Lumumba
GRNTI 68.41 Ветеринария
The article describes a study on comparative efficacy and safety of BARS® insectoacaricidal drops developed by «AVZ» Ltd (Russia), which contains fipronil, cyfluthrin, piperonylbutoxide and diflubenzuron as active substances, as well as auxiliary substances and Frontline Spot On (Boehringer Ingelheim Animal Health France SCS, France), the active substance of which is fipronil ‒ 10 %, as well as auxiliary substances. Purpose of the study. To compare acaricidal efficacy of BARS® insectoacaricidal drops and Frontline Spot On against ixodid ticks attacking dogs and cats. Materials and methods. The studies were conducted in parallel groups of 10 animals each: group 1 ‒ experimental group (tested preparation BARS® insectoacaricidal drops), group 2 ‒ comparison preparation (Frontline Spot On). The preparations were applied in accordance with the instructions once by drop application to dry intact skin in places inaccessible for licking. Then the acute and residual acaricidal efficacy was evaluated – (the duration of acaricidal action, day). Results and conclusions. Acute acaricidal efficacy of BARS® insectoacaricidal drops and comparison preparation ‒ Frontline Spot On, in spontaneous ixodidosis of cats and dogs in 3 hours after treatment was 100 %. The preparation BARS® insectocaricidal drops 1 hour and 2 hours after treatment of animals is more effective on average by 8.2…8.3 % than Frontline Spot On. The duration of acaricidal action was almost equivalent in the studied drugs and lasted from 30 to 50 days when using the drug BARS® insecticidal drops, and from 25 to 50 days when using the drug Frontline Spot On. The conducted studies allow us to conclude about high efficiency and safety of BARS® insectoacaricidal drops developed by «AVZ» Ltd. The domestic preparation can fully meet the needs of veterinary specialists in conducting prophylactic acaricidal measures of small domestic animals along with foreign preparation.
medicinal product, effectiveness, ixode ticks, BARS® insectoacaricidal drops, Frontline Spot On
1. Arisov M.V., Arisova G.B., Koshkarev E.A., Stepanova I.A., Ispol`zovanie «Neoterika protekto 12» protiv iksodovy`x kleshhej u sobak i koshek [The use of "Neoteric protecto 12" against ixodic ticks in dogs and cats], Rossijskij parazitologicheskij zhurnal, 2018, Vol. 12, No. 1, pp. 59-63.
2. Vasilevich, F.I., Nikanorova A.M., E`ksperimental`ny`j iksodidoz [Experimental ixodidosis] Teoriya i praktika bor`by` s parazitarny`mi boleznyami, 2022, No. 23, pp. 118-123.
3. Gomzyakova N.V., Nikanorova A.M., Iksodidozy` sobak v g. Kaluga [Ixodidoses of dogs in Kaluga], V knige: Innovacionny`j vektor razvitiya agrarnoj nauki [In the book: Innovative vector of agricultural science development], Moscow, 2022, pp. 155-156
4. Bushey D.F., Fipronil mode of action research summary. Unpublished memo prepared by Rhone-Poulenc Agrochimie Co., Research Triangle Park Biochemistry Group. Submitted to WHO by Rhone- Poulenc, Inc., Research Triangle Park, NC, USA, 1993. Available at: https://apvma.gov.au/sites/default/files/publication/15191-fipronil-prf-vol2-animal-safety-literature_0.pdf
5. Cole L.M., Nicholson R.A., Casida J.E., Action of phcnylpyrazolc insecticides at the GABA- gated chloride channel, Pestic. Biochem. Physiol., 1993, No. 46, pp. 47-54.
6. Dimov I. Kapli na holku rolfclub combo - novoe vysokoeffektivnoe sredstvo v bor'be s iksodovymi kleshchami u koshek i sobak [Rolfclub combo drops on the withers - a new highly effective remedy in the fight against ixodid ticks in cats and dogs], VetPharma, 2012, No. 1-2 (6-7), pp. 54-56.
7. EMEA/MRL/486/98 - FINAL. Available at: https://fsvps.gov.ru/sites/default/files/fsvps-docs/ru/importExport/ssagpz/files/gso_2481.pdf
8. EMEA/MRL/537/98 - FINAL. Available at: https://www.ema.europa.eu/en/documents/mrl-report/piperonyl-butoxide-summary-report-committee-veterinary-medicinal-products_en.pdf
9. EMEA/MRL/746/00 - FINAL. Available at: https://www.ema.europa.eu/en/documents/mrl-report/tiamulin-summary-report-3-committee-veterinary-medicinal-products_en.pdf
10. Gant D.B., Chalmers A.E., Wolff M.A., Fipronil: A novel insecticide acting at the GABA receptor. Poster presented at the Eighth International Congress of Pesticide Chemistry, Washington DC by Rhone-Poulenc Agrochimie Co., Department of Biochemistry/Biotechnology, Research Triangle Park, NC, 1994
11. GOST 12.1.007-76 SSBT. Vrednye veshchestva. Klassifikaciya i obshchie trebovaniya bezopasnosti (s Izmeneniyami N 1, 2) [Harmful substances. Classification and general safety requirements (with changes No. 1,2)].
12. Otchet EALS/PDK/486/98 - Okonchatel'naya versiya Noyabr' 1998 g. [Report EALS/PDK/486/98 - Final November 1998].
13. Otchet EMEA EALS/PDK/746/00 - Okonchatel'naya versiya Iyul' 2000 g [Report EMEA ELS/PDK/746/00 - Final version July 2000].
14. http://www.inchem.org/documents/jmpr/jmpmono/v097pr09.htm