GRNTI 68.41 Ветеринария
Feline infectious peritonitis is a difficult-to-treat disease caused by a highly virulent biotype of a widespread feline coronavirus. Vetstem LLC has developed a drug Ipecon® based on a low-molecular compound with a direct antiviral effect against RNA-containing viruses. Ipekon® has passed all preclinical studies. The purpose of the study: to evaluate the therapeutic efficacy of the veterinary drug Ipecon® in the treatment of feline infectious peritonitis. Materials and methods: the study included 28 cats, aged 6 months to 11 years: 18 animals with exudative and 8 with non-exudative («dry») form of IPK/FIP. The animals were divided into 3 groups, taking into account the starting single dose of the drug Ipecon®: 8 mg/kg, 10 mg/kg, 12 mg/kg. The finished solution was administered subcutaneously daily, once a day, with an interval between injections of 24 hours during the entire course of treatment. The assessment of the treatment effectiveness was comprehensive, taking into account the data of the clinical examination, the results of general clinical and biochemical blood tests, ultrasound of internal organs. Results: of the 28 animals with diagnosed IPC/FIP included in the study, 4 (14.3%) patients had a fatal outcome caused by multiple organ failure; 85.7 % of patients had the status of «clinical recovery» at the end of the course of treatment. Good tolerability of the drug Ipecon® has been established with repeated subcutaneous use. Despite the noted discomfort during administration, there were no signs of intoxication or clinically pronounced abnormalities, deterioration in the functions of organs and systems. During the use of the drug Ipecon®, only one case was noted.
Feline infectious peritonitis, FIP, feline coronavirus, Ipecon®, Vefinavir, VS-121354, viral protease inhibitor
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