LLC AG Aspect (Scientific consultant)
LLC «RDE «Astrapharm» (Scientific consultant)
Russian Federation
LLC «AG «Aspect» (Veterinarian)
LLC «RDE «Astrapharm» (Leading veterinarian)
LLC «BioFeron» (Leading veterinarian)
employee
Russian Federation
LLC «RDE «Astrapharm» (Chief science specialist)
LLC «BioFeron» (Chief science specialist)
employee
Russian Federation
GRNTI 68.41 Ветеринария
Based on the results of this study, it was established that oral administration of the drug Course Uspokoin in tablets to cats for 380 days at doses of 18.0 mg/kg and 25.2 mg/kg does not have a negative effect on animals on their general condition and behavior, body weight dynamics , animal behavior. does not determine body temperature, measures pulse and population density, morphological composition and biochemical parameters of blood.
succinate trazodone, Kurs Uspokoin tablets, cats, chronical toxicity, tolerability, safety
1. Voith, V.L. Attachment of people to companion animals / V.L. Voith // Vet Clin North Am Small Anim Pract. ‒ 1985. ‒No. 15. ‒ pp. 289-295.
2. Patronek, G. Attitudes, procedures, and delivery of behavior services by veterinarians in small animal practice / G. Patronek, M. Dodman // J Am Vet Med Assoc. ‒ 1999. ‒ No. 215. ‒ pp. 1606-1611.
3. Salman, M.D. Behavioral reasons for relinquishment of dogs and cats to 12 shelters / M.D. Salman, J. Hutchison, R. Ruch-Gallie, et al. // J Appl Anim Welf Sci. ‒ 2000. ‒ No. 3. ‒ pp. 93-106.
4. Scarlett, J.M. The role of veterinary practitioners in reducing dog and cat relinquishments and euthanasias / J.M. Scarlett, M.D. Salman, J.G. New, et al. // J Am Vet Med Assoc. ‒ 2002. ‒ No. 220. ‒ pp. 306-311.
5. Hammerle, M. AAHA canine and feline behavior management guidelines ‒ M. Hammerle, C. Horst, E. Levine, et al. // J Am Anim Hosp Assoc. ‒ 2015. ‒ No. 51. ‒ pp. 205-221.
6. Seksel, K. Use of clomipramine in the treatment of anxiety-related and obsessive-compulsive disorders in cats / K. Seksel, M.J. Lindeman // Aust Vet J. ‒ 1998. ‒ No. 76. ‒ pp. 317-320.
7. Griffith, C.A. Effects of a synthetic facial pheromone on the behavior of cats / C.A. Griffith, E.S. Steigerwald, C.A.T. Buffington // J Am Vet Med Assoc. ‒ 2000. ‒ No. 217. ‒ pp. 1154-1156.
8. Pryor, P.A. Effects of a selective serotonin reuptake inhibitor on urine spraying behavior in cats / P.A. Pryor, B.L. Hart, K.D. Cliff, et al. // J Am Vet Med Assoc. ‒ 2001. ‒ No. 219. ‒ pp. 1557-1561.
9. Dramard, V. Clinical efficacy of L-theanine tablets to reduce anxiety-related emotional disorders in cats: a pilot open-label clinical trial / V. Dramard, L. Kern, J. Hofmans, et al. // J Vet Behav. ‒ 2007. ‒ No. 5. ‒ pp. 85-86.
10. van Haaften, K.A. Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination / K.A. van Haaften, L.R.E. Forsythe, E.A. Stelow, et al. // J Am Vet Med Assoc. ‒ 2017. ‒ No. 251. ‒ pp. 1175-1181.
11. Sordo, L. Cognitive Dysfunction in Cats: Update on Neuropathological and Behavioural Changes Plus Clinical Management / L. Sordo, D.A. Gunn-Moore // Vet Rec. ‒ 2021 Jan. ‒ No. 188(1). ‒ e3. doi:https://doi.org/10.1002/vetr.3. Epub 2021 Jan 12. PMID: 34651755.
12. Gunn-Moore, D. Cognitive dysfunction and the neurobiology of ageing in cats / D. Gunn-Moore, K. Moffat, L-A. Christie, E. Head // J Small Anim Pract. ‒ 2007. ‒ No. 48. ‒ pp. 546-53. https://doi.org/10.1111/j.1748- 5827.2007.00386.x.
13. Landsberg, G.M. Cognitive dysfunction in cats: a syndrome we used to dismiss as ’old age’ / G.M. Landsberg, S. Denenberg, J.A. Araujo // J Feline Med Surg. ‒ 2010. ‒ No. 12. ‒ pp. 837-48.
14. Alcántara-López, M.G. Trazodone, an atypical antidepressant with anxiolytic and sedative properties / M.G. Alcántara-López, A.G. Gutiérrez-García, M. Hernández-Lozano, C.M. Contreras // Arch Neurocien. ‒ 2009. ‒ No. 14(4). ‒ pp. 249-257.
15. Cuomo, A. Trazodone: a multifunctional antidepressant. Evaluation of its properties and real-world use / A. Cuomo, A. Bianchetti, A. Cagnin // Journal of Gerontology and Geriatrics. ‒ 2021 june. ‒ Vol. 69. ‒ Iss. 2 16. Haria, M. Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders / M. Haria, A. Fitton, D. McTavish // Drugs Aging. ‒ 1994. ‒ No. 4(4). ‒ pp. 331.
16. Stahl, S.M. Mechanism of Action of Trazodone: a Multifunctional Drug / Stahl S.M. ‒ Published online by Cambridge University Press: 07 November 2014.
17. Fagiolini, A. Rediscovering Trazodone for the Treatment of Major Depressive Disorder / A. Fagiolini, A. Comandini // CNS Drugs. ‒ 2012. ‒ No. 26(12). ‒ pp. 1033-1049.
18. Fagiolini, A. Rediscovering trazodone for the treatment of major depressive disorder / A. Fagiolini, A. Comandini, M. Catena Dell'Osso, S. Kasper // CNS Drugs. ‒ 2012 Dec. ‒ No. 26(12). ‒ pp. 1033-49.
19. Khouzam, H.R. A review of trazodone use in psychiatric and medical conditions / H.R. Khouzam // Postgrad. Med. ‒ 2017. ‒ No. 129. ‒ pp. 140-148.
20. Orlando, J.M. Use of oral trazodone for sedation in cats: A pilot study / J.M. Orlando, B.C. Case, A.E. Thomson, E. Griffith, B.L. Sherman // J. Feline Med. Surg. ‒ 2016. ‒ No. 18. ‒ pp. 476-482.
21. Stevens, B.J. Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety / B.J. Stevens, E.M. Frantz, J.M. Orlando, E. Griffi th, L.B. Harden et al. // J. Am. Vet. Med. Assoc. ‒ 2016. ‒ No. 249. ‒ pp. 202-207.
22. Chea, V., Trazodone: A Review of its pharmacological properties and its off-label use in dogs and cats / V. Chea, M. Giorgi // American Journal of Animal and Veterinary Sciences. ‒ 2017. ‒ No. 12 (4). ‒ pp. 188-194.
23. Orlando, J.M. Use of oral trazodone for sedation in cats: A pilot study / J.M. Orlando, B.C. Case, A.E. Thomson, E. Griffith, B.L. Sherman // J. Feline Med. Surg. ‒ 2016. ‒ No. 18. ‒ pp. 476-482.
24. Stevens, B.J. Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety / B.J. Stevens, E.M. Frantz, J.M. Orlando, E. Griffith, L.B. Harden et al. // J. Am. Vet. Med. Assoc. ‒ 2016. ‒ No. 249. ‒ pp. 202-207.
25. Beloglazov, D.V. Trazodona sukcinat — novye vozmozhnosti farmakologicheskoy korrekcii situacionnyh povedencheskih otkloneniy u sobak i koshek / D.V. Beloglazov, S.V. Mukaseev, O.A. Zeynalov // Rossiyskiy veterinarnyy zhurnal. ‒ 2021. ‒ № 4. ‒ S. 5-13.
26. Orobec, V.A. Toksikologicheskaya harakteristika novogo preparata dlya situacionnoy korrekcii povedencheskih otkloneniy u koshek i sobak Ekspress Uspokoin® tabletki / V.A. Orobec, D.V. Beloglazov, S.V. Mukaseev, O.A. Zeynalov // Rossiyskiy veterinarnyy zhurnal. ‒ 2023. ‒ № 1 ‒ S. 10-18.
27. Beloglazov, D.V. Ocenka effektivnosti novogo preparata Ekspress Uspokoin® tabletki pri situacionnoy korrekcii povedencheskih problem u sobak / D.V. Beloglazov, S.V. Mukaseev, O.A. Zeynalov // Sovremennaya veterinarnaya medicina. ‒ 2023. ‒ № 1. ‒ C. 18-22.
28. Beloglazov, D.V. Ocenka effektivnosti novogo preparata Ekspress Uspokoin® tabletki pri situacionnoy korrekcii povedencheskih problem u koshek / D.V. Beloglazov, S.V. Mukaseev, O.A. Zeynalov // Rossiyskiy veterinarnyy zhurnal. ‒ 2023. ‒ № 2 ‒ S. 14-22.
29. Elizarova E.A., Beloglazov D.V., Zeynalov O.A., Mukaseev S.V., Ocenka effektivnosti novogo lekarstvennogo preparata Kurs Uspokoin tabletki dlya korrekcii vozrastnyh kognitivnyh narusheniy u koshek / D.V. Beloglazov, O.A. Zeynalov, S.V. Mukaseev // Rossiyskiy veterinarnyy zhurnal. ‒ 2024. ‒ № 3 ‒ S. 27-33.
30. Settimo, L. Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets / L. Settimo, D. Taylor // Journal of Psychopharmacology. ‒ 2018. ‒ No. 32(1). ‒ pp. 96-104.
